Fleming K A, McMichael A, Morton J A, Woods J, McGee J O
J Clin Pathol. 1981 Jul;34(7):779-84. doi: 10.1136/jcp.34.7.779.
With a monoclonal antibody which reacts with all HLA class 1 antigens it was found that these antigens are not uniformly distributed in all nucleated cells. Rather HLA class 1 antigens are restricted in their distribution to lymphoid cells, endothelial cells of small vessels, and certain epithelia including mammary duct cells. These antigens were not detected on hepatocytes, specialised cells of the central nervous system, or on the tumour cells of 8 out of 17 human mammary cancers. Given the hypothesis that T cells only respond to foreign antigens on cells which share a common major histocompatibility antigen, these results imply that the T cell responses to viral infections of hepatocytes--for example, hepatitis B virus and the CNS--for example, subacute sclerosing encephalitis, are mediated through an antigen system other than HLA class 1. The absence of HLA class 1 antigen on many mammary cancer cells may be of prognostic significance if T cell modulation of tumour growth is mediated through this class of antigens.
使用一种能与所有HLA - Ⅰ类抗原发生反应的单克隆抗体，发现这些抗原并非均匀地分布于所有有核细胞中。相反，HLA - Ⅰ类抗原的分布局限于淋巴细胞、小血管内皮细胞以及某些上皮细胞，包括乳腺导管细胞。在肝细胞、中枢神经系统的特殊细胞以及17例人类乳腺癌中的8例肿瘤细胞上未检测到这些抗原。鉴于T细胞仅对具有共同主要组织相容性抗原的细胞上的外来抗原作出反应这一假说，这些结果表明，T细胞对肝细胞病毒感染（例如乙型肝炎病毒）以及中枢神经系统感染（例如亚急性硬化性全脑炎）的反应是通过HLA - Ⅰ类以外的抗原系统介导的。如果肿瘤生长的T细胞调节是通过这类抗原介导的，那么许多乳腺癌细胞上缺乏HLA - Ⅰ类抗原可能具有预后意义。
