恶性非霍奇金淋巴瘤中的免疫球蛋白异常
Immunoglobulin abnormalities in malignant non-Hodgkin's lymphoma.
作者信息
Economidou J, Terzoglou K, Anagnostou D, Nikiforakis E M, Papajannis A
出版信息
Scand J Haematol. 1984 Aug;33(2):123-8. doi: 10.1111/j.1600-0609.1984.tb02386.x.
The association of monoclonal gammopathy and lymphoma was investigated in 100 consecutive, untreated cases of chronic lymphocytic leukaemia (CLL) and non-Hodgkin's lymphoma (NHL) of B-cell type, classified according to the criteria of Lukes & Collins (9). The overall incidence of monoclonal immunoglobulins (Ig) was 24%. The highest incidence (57%) was seen in plasmacytoid lymphocytic lymphoma and the lowest (7.9%) in cases of CLL. IgM was the predominant class of monoclonal Ig. It is concluded that the presence of monoclonal gammopathy in NHL reflects the stage of differentiation and maturation of the malignant B-cell clone.
根据卢克斯和柯林斯（9）的标准分类，对100例连续的未经治疗的B细胞型慢性淋巴细胞白血病（CLL）和非霍奇金淋巴瘤（NHL）病例进行了单克隆丙种球蛋白病与淋巴瘤关联的研究。单克隆免疫球蛋白（Ig）的总体发生率为24%。在浆细胞样淋巴细胞淋巴瘤中发生率最高（57%），在CLL病例中最低（7.9%）。IgM是单克隆Ig的主要类型。结论是NHL中存在单克隆丙种球蛋白病反映了恶性B细胞克隆的分化和成熟阶段。
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