肺癌的演进：免疫在其中扮演了什么角色？

Lung Cancer Evolution: What's Immunity Got to Do with It?

机构信息

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunogenomics and Precision Oncology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunogenomics and Precision Oncology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Radiation Oncology, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

出版信息

Cancer Cell. 2019 May 13;35(5):711-713. doi: 10.1016/j.ccell.2019.04.009.

DOI:10.1016/j.ccell.2019.04.009

PMID:31085173

Abstract

During the development and progression of tumors, cancer cells undergo clonal selection due to a variety of genetic and microenvironmental factors. A recent report presents insights demonstrating the interplay between neoantigens and the immune system in untreated non-small-cell lung cancers.

摘要

在肿瘤的发生和发展过程中，由于多种遗传和微环境因素，癌细胞经历克隆选择。最近的一份报告提供了关于未治疗的非小细胞肺癌中新抗原与免疫系统相互作用的见解。