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1
Monoclonal cytolytic T-cell lines.单克隆细胞毒性T细胞系
J Exp Med. 1979 Jan 1;149(1):273-8. doi: 10.1084/jem.149.1.273.
2
Specificity studies on cytolytic T lymphocytes directed against murine leukemia virus-induced tumors. Analysis of monoclonal cytolytic T lymphocytes.针对鼠白血病病毒诱导肿瘤的细胞毒性T淋巴细胞的特异性研究。单克隆细胞毒性T淋巴细胞分析。
J Exp Med. 1982 Apr 1;155(4):1050-62. doi: 10.1084/jem.155.4.1050.
3
Alloreactive cloned T cell lines. IV. Interaction of alloantigen and T cell growth factors (TCGF) to stimulate cloned cytolytic T lymphocytes.同种异体反应性克隆T细胞系。IV. 同种异体抗原与T细胞生长因子（TCGF）相互作用以刺激克隆性细胞毒性T淋巴细胞
J Immunol. 1981 Jul;127(1):391-2.
4
Characterization of cloned murine cytolytic T cell lines.克隆化小鼠细胞毒性T细胞系的特性分析
J Immunol. 1980 Oct;125(4):1481-6.
5
Alloreactive cloned T cell lines. III. Accessory cell requirements for the growth of cloned cytolytic T lymphocytes.同种异体反应性克隆T细胞系。III. 克隆细胞毒性T淋巴细胞生长的辅助细胞需求。
J Immunol. 1981 Apr;126(4):1404-8.
6
Antigenic specificity of the cytolytic T lymphocyte response to murine sarcoma virus-induced tumors. III. Characterization of cytolytic T lymphocyte clones specific for Moloney leukemia virus-associated cell surface antigens.细胞毒性T淋巴细胞对鼠肉瘤病毒诱导肿瘤的抗原特异性。III. 对莫洛尼白血病病毒相关细胞表面抗原具有特异性的细胞毒性T淋巴细胞克隆的特性
J Exp Med. 1980 Nov 1;152(5):1210-25. doi: 10.1084/jem.152.5.1210.
7
Inhibition of cytolytic T lymphocyte clones reactive with Moloney leukemia virus-associated antigens by monoclonal antibodies: a direct approach to the study of H-2 restriction.单克隆抗体对与莫洛尼白血病病毒相关抗原起反应的细胞溶解T淋巴细胞克隆的抑制作用：H-2限制性研究的直接方法
J Immunol. 1981 Feb;126(2):482-5.
8
Production of macrophage activating factor by cytolytic and noncytolytic T lymphocyte clones.细胞毒性和非细胞毒性T淋巴细胞克隆产生巨噬细胞激活因子。
Adv Exp Med Biol. 1982;155:493-8. doi: 10.1007/978-1-4684-4394-3_51.
9
Distinct proliferative T cell clonotypes are generated in response to a murine retrovirus-induced syngeneic T cell leukemia: viral gp70 antigen-specific MT4+ clones and Lyt-2+ cytolytic clones which recognize a tumor-specific cell surface antigen.针对小鼠逆转录病毒诱导的同基因T细胞白血病，会产生不同的增殖性T细胞克隆型：病毒gp70抗原特异性MT4 +克隆和识别肿瘤特异性细胞表面抗原的Lyt-2 +溶细胞克隆。
J Immunol. 1985 Jul;135(1):703-13.
10
T-cell lines which cooperate in generation of specific cytolytic activity.在特异性细胞溶解活性产生过程中协同作用的T细胞系。
Nature. 1979 Mar 8;278(5700):171-3. doi: 10.1038/278171a0.

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Editorial: A Living History of Immunology.社论：免疫学的鲜活历史
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Commentary: Production and Characterization of Monoclonal Antibodies to Human Interleukin 2: Strategy and Tactics.评论：抗人白细胞介素2单克隆抗体的制备与特性鉴定：策略与方法
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Characterization of an IL-12 p40/p35 Truncated Fusion Protein That can Inhibit the Action of IL-12.一种可抑制白细胞介素-12作用的白细胞介素-12 p40/p35截短融合蛋白的特性分析
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αβ TCR-mediated recognition: relevance to tumor-antigen discovery and cancer immunotherapy.αβ TCR 介导的识别：与肿瘤抗原发现和癌症免疫治疗的相关性。
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本文引用的文献

1
Long-term culture of human antigen-specific cytotoxic T-cell lines.人类抗原特异性细胞毒性T细胞系的长期培养。
J Exp Med. 1978 Oct 1;148(4):1093-8. doi: 10.1084/jem.148.4.1093.
2
Cloned T-cell lines with specific cytolytic activity.具有特异性细胞溶解活性的克隆T细胞系。
Curr Top Microbiol Immunol. 1978;81:176-87. doi: 10.1007/978-3-642-67448-8_29.
3
T cell growth factor: parameters of production and a quantitative microassay for activity.T细胞生长因子：产生参数及活性的定量微量测定法。
J Immunol. 1978 Jun;120(6):2027-32.
4
Clones of alloreactive T cells.
Nature. 1978 Apr 13;272(5654):617-8. doi: 10.1038/272617a0.
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Long term culture of tumour-specific cytotoxic T cells.肿瘤特异性细胞毒性T细胞的长期培养。
Nature. 1977 Jul 14;268(5616):154-6. doi: 10.1038/268154a0.
6
In vitro generation of tumor-specific cytotoxic lymphocytes. Secondary allogeneic mixed tumor lymphocyte culture of normal murine spleen cells.肿瘤特异性细胞毒性淋巴细胞的体外生成。正常小鼠脾细胞的二次同种异体混合肿瘤淋巴细胞培养。
J Exp Med. 1977 Aug 1;146(2):468-82. doi: 10.1084/jem.146.2.468.

单克隆细胞毒性T细胞系

Monoclonal cytolytic T-cell lines.

作者信息

Baker P E, Gillis S, Smith K A

出版信息

J Exp Med. 1979 Jan 1;149(1):273-8. doi: 10.1084/jem.149.1.273.

DOI:10.1084/jem.149.1.273
PMID:310861
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2184737/
Abstract

Monospecific cloned cytolytic T-lymphocyte lines have been created utilizing T-cell growth factor. The clones were found to retain their cytolytic specificity after prolonged culture and monospecific function was demonstrated by subcloning procedures. Thus, detailed studies of the phenotypic and functional characteristics of monospecific, homogeneous, cytolytic T lymphocytes will now be possible.

摘要

利用T细胞生长因子建立了单特异性克隆细胞毒性T淋巴细胞系。发现这些克隆在长期培养后仍保留其细胞毒性特异性，并且通过亚克隆程序证明了其单特异性功能。因此，现在有可能对单特异性、同质的细胞毒性T淋巴细胞的表型和功能特性进行详细研究。