单克隆细胞毒性T细胞系
Monoclonal cytolytic T-cell lines.
作者信息
Baker P E, Gillis S, Smith K A
出版信息
J Exp Med. 1979 Jan 1;149(1):273-8. doi: 10.1084/jem.149.1.273.
Abstract
Monospecific cloned cytolytic T-lymphocyte lines have been created utilizing T-cell growth factor. The clones were found to retain their cytolytic specificity after prolonged culture and monospecific function was demonstrated by subcloning procedures. Thus, detailed studies of the phenotypic and functional characteristics of monospecific, homogeneous, cytolytic T lymphocytes will now be possible.
摘要
利用T细胞生长因子建立了单特异性克隆细胞毒性T淋巴细胞系。发现这些克隆在长期培养后仍保留其细胞毒性特异性，并且通过亚克隆程序证明了其单特异性功能。因此，现在有可能对单特异性、同质的细胞毒性T淋巴细胞的表型和功能特性进行详细研究。
相似文献
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Monoclonal cytolytic T-cell lines.单克隆细胞毒性T细胞系
J Exp Med. 1979 Jan 1;149(1):273-8. doi: 10.1084/jem.149.1.273.
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本文引用的文献
1
Long-term culture of human antigen-specific cytotoxic T-cell lines.人类抗原特异性细胞毒性T细胞系的长期培养。
J Exp Med. 1978 Oct 1;148(4):1093-8. doi: 10.1084/jem.148.4.1093.
2
Cloned T-cell lines with specific cytolytic activity.具有特异性细胞溶解活性的克隆T细胞系。
Curr Top Microbiol Immunol. 1978;81:176-87. doi: 10.1007/978-3-642-67448-8_29.
3
T cell growth factor: parameters of production and a quantitative microassay for activity.T细胞生长因子：产生参数及活性的定量微量测定法。
J Immunol. 1978 Jun;120(6):2027-32.
4
Clones of alloreactive T cells.
Nature. 1978 Apr 13;272(5654):617-8. doi: 10.1038/272617a0.
5
Long term culture of tumour-specific cytotoxic T cells.肿瘤特异性细胞毒性T细胞的长期培养。
Nature. 1977 Jul 14;268(5616):154-6. doi: 10.1038/268154a0.
6
In vitro generation of tumor-specific cytotoxic lymphocytes. Secondary allogeneic mixed tumor lymphocyte culture of normal murine spleen cells.肿瘤特异性细胞毒性淋巴细胞的体外生成。正常小鼠脾细胞的二次同种异体混合肿瘤淋巴细胞培养。
J Exp Med. 1977 Aug 1;146(2):468-82. doi: 10.1084/jem.146.2.468.
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