Department of Pharmacology and Physiology, Saint Louis University School of Medicine, 1402 S. Grand Blvd., Saint Louis, MO, 63104, USA.
Department of Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC, 29425-8908, USA.
Brain Struct Funct. 2019 Jun;224(5):1925-1932. doi: 10.1007/s00429-019-01879-9. Epub 2019 May 13.
Previous studies have shown that infusion of a GABA receptor antagonist, such as bicuculline (bic), into the ventral (pallidum VP) of rats elicits vigorous ingestion in sated subjects and abnormal pivoting movements. Here, we assessed if the ingestive effects generalize to the lateral preoptic area (LPO) and tested both effects for modulation by dopamine receptor signaling. Groups of rats received injections of the dopamine D2 receptor antagonist, haloperidol (hal), the D1 antagonist, SCH-23390 (SCH), or vehicle (veh) followed by infusions of bic or veh into the VP or LPO. Ingestion effects were not observed following LPO bic infusions. Compulsive ingestion associated with VP activation was attenuated by hal, but not SCH. VP bic-elicited pivoting was attenuated by neither hal, nor SCH.
先前的研究表明，向大鼠腹侧苍白球（VP）输注 GABA 受体拮抗剂，如荷包牡丹碱（bic），会引起已饱食动物的强烈摄食和异常的旋转运动。在这里，我们评估了这种摄食效应是否会推广到外侧视前区（LPO），并测试了多巴胺受体信号对这两种效应的调节作用。几组大鼠接受了多巴胺 D2 受体拮抗剂氟哌啶醇（hal）、D1 拮抗剂 SCH-23390（SCH）或载体（veh）的注射，然后将 bic 或 veh 输注到 VP 或 LPO。LPO 输注 bic 后没有观察到摄食效应。VP 激活引起的强迫性摄食被 hal 减弱，但 SCH 没有。VP bic 引起的旋转运动既不受 hal 也不受 SCH 的影响而减弱。
