Franklin C D, Craig G T
Oral Surg Oral Med Oral Pathol. 1987 Mar;63(3):335-9. doi: 10.1016/0030-4220(87)90200-3.
Tumors were allowed to develop in the cheek pouches in two groups of hamsters following topical application three times per week of a 0.5% solution of 7, 12-dimethylbenz(alpha)anthracene (DMBA) in liquid paraffin administered for 10 weeks. Two control groups received no DMBA treatment. After carcinogen application, the animals in one DMBA-treated group and those in one of the control groups were given indomethacin daily; this was administered through the oral route for an additional 10 weeks. At this time, all of the animals were killed and their cheek pouches, the draining cervical lymph nodes, and other organs were removed for examination. The number and size of tumors in each pouch were recorded, and each pouch was weighed. Indomethacin, in the dosage administered, was not found to cause regression of established tumors. The effects of prostaglandins, indomethacin, and other prostaglandin-synthesis inhibitors in tumor tissue are discussed. It is suggested that more knowledge is needed about the role of prostaglandins, and the related products of AA metabolism, in squamous cell cancer before indomethacin is used therapeutically.
在两组仓鼠的颊囊中诱发肿瘤，每周三次局部涂抹0.5%的7,12 - 二甲基苯并(α)蒽（DMBA）的液状石蜡溶液，持续10周。两个对照组不接受DMBA处理。在涂抹致癌物后，一个DMBA处理组的动物和一个对照组的动物每天给予吲哚美辛；通过口服途径给药，持续额外的10周。此时，所有动物被处死，取出它们的颊囊、引流的颈部淋巴结和其他器官进行检查。记录每个颊囊中肿瘤的数量和大小，并对每个颊囊称重。在所给予的剂量下，未发现吲哚美辛能使已形成的肿瘤消退。讨论了前列腺素、吲哚美辛和其他前列腺素合成抑制剂在肿瘤组织中的作用。建议在将吲哚美辛用于治疗之前，需要更多关于前列腺素以及花生四烯酸代谢相关产物在鳞状细胞癌中作用的知识。
