Lambert P R
Otolaryngol Head Neck Surg. 1986 Sep;95(2):193-9. doi: 10.1177/019459988609500211.
A prospective, double-blind crossover study design was used in the evaluation of the role of prednisone in the treatment of a chronic middle ear effusion. Sixty children with an effusion--of at least 2 months' duration--randomly received either prednisone or placebo for 2 weeks. One week later they were re-evaluated. If the effusion had resolved, they were followed periodically; if the effusion persisted, they were given the crossover regimen and reevaluated. Sixty percent of the patients' effusions cleared, but there was no statistical difference between the prednisone and placebo groups. The amount of hearing recovery was also the same for both treatment regimens. Subdividing the patients on the basis of effusion duration, unilateral vs. bilateral effusions, or history of ventilation tubes or antibiotics failed to identify a subgroup of individuals who might benefit from a short-term course of oral steroids.
一项前瞻性、双盲交叉研究设计被用于评估泼尼松在治疗慢性中耳积液中的作用。60名患有至少持续2个月积液的儿童被随机给予泼尼松或安慰剂，为期2周。1周后对他们进行重新评估。如果积液已消退，对他们进行定期随访；如果积液持续存在，给予交叉治疗方案并重新评估。60%的患者积液消退，但泼尼松组和安慰剂组之间无统计学差异。两种治疗方案的听力恢复程度也相同。根据积液持续时间、单侧与双侧积液、或是否有通气管或抗生素使用史对患者进行细分，未能识别出可能从短期口服类固醇疗程中获益的亚组人群。
