Podoshin L, Fradis M, Ben-David Y, Faraggi D
Department of Otolaryngology Bnai Zion Medical Center, Haifa, Israel.
Arch Otolaryngol Head Neck Surg. 1990 Dec;116(12):1404-6. doi: 10.1001/archotol.1990.01870120050007.
One hundred thirty-six children with otitis media with effusion of at least 2 months' duration were investigated in a strict, double-blind, randomized prospective study to evaluate the efficacy of oral steroids in the treatment of this disease. The results of our study showed a significant complete and partial recovery from otitis media with effusion in the group treated by a combination of antibiotics (amoxicillin) and oral steroids (prednisone), compared with an amoxicillin-treated group and a placebo-treated group. We believe that this treatment mostly benefits children aged 4 to 10 years without oversized adenoids. The findings of our study imply that a combined course of antibiotics and oral steroids deserves its place as a routine conservative trial before surgery.
在一项严格的、双盲、随机前瞻性研究中，对136名患有至少2个月持续性中耳积液的儿童进行了调查，以评估口服类固醇治疗该病的疗效。我们的研究结果显示，与阿莫西林治疗组和安慰剂治疗组相比，在使用抗生素（阿莫西林）和口服类固醇（泼尼松）联合治疗的组中，中耳积液有显著的完全和部分恢复。我们认为这种治疗对4至10岁且腺样体不过大的儿童最为有益。我们的研究结果表明，在手术前，抗生素和口服类固醇的联合疗程作为常规保守试验是值得的。
