混合性结缔组织病及其他结缔组织病中的游离血清核糖核蛋白
Free serum ribonucleoprotein in mixed connective tissue disease and other connective tissue diseases.
作者信息
Fishbein E, Ramos-Niembro F, Alarcon-Segovia D
出版信息
J Rheumatol. 1978 Winter;5(4):384-90.
Free ribonucleoprotein (RNP) was found by means of a hemagglutination inhibition assay in 21 sera from 11 of 25 patients with mixed connective tissue disease (MCTD) who had 299 sera studied. Free RNP tended to appear when anti-RNP antibody titers fell or when prednisone was initiated or increased. Five of 72 SLE patients (211 sera) had free RNP in at least one serum. Three of them had anti-RNP antibodies in other sera. Free serum RNP was found in one of 20 patients with scleroderma and in two of seven patients with connective tissue disease "overlap" syndromes without anti-RNP.
在对25例混合性结缔组织病（MCTD）患者的299份血清进行研究时，通过血凝抑制试验在其中11例患者的21份血清中发现了游离核糖核蛋白（RNP）。当抗RNP抗体滴度下降，或开始使用泼尼松或增加其剂量时，游离RNP往往会出现。72例系统性红斑狼疮（SLE）患者（211份血清）中有5例至少在一份血清中检测到游离RNP。其中3例在其他血清中有抗RNP抗体。在20例硬皮病患者中的1例以及7例无抗RNP的结缔组织病“重叠”综合征患者中的2例发现了游离血清RNP。
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