Lang Nina, Dick Julika, Slynko Alla, Schulz Carsten, Dimitrakopoulou-Strauss Antonia, Sachpekidis Christos, Enk Alexander H, Hassel Jessica C
Department of Dermatology & National Center for Tumor Diseases, University Hospital Heidelberg, Germany.
Department of Mathematics, Natural & Economic Sciences, University of Applied Sciences, Ulm, Germany.
Immunotherapy. 2019 Jun;11(8):667-676. doi: 10.2217/imt-2018-0146.
Autoimmune colitis is a typical and possible severe side effect among patients treated with ipilimumab. We prospectively included 100 patients with metastasized melanoma under ipilimumab treatment in a radiological study of F-fluorodeoxyglucose positron emission tomography-computed tomography (F-FDG PET-CT). PET evidence of pancolitis ('PET-colitis') was correlated with clinical variables. We observed a significant correlation between PET-colitis and clinically significant diarrhoea, although PET-colitis was more frequent (49 vs 29% of patients, respectively). Neither PET-colitis nor diarrhoea was significantly correlated with response to therapy. Other immune-related adverse events, however, such as hypophysitis and hepatitis were associated with response to therapy and overall survival. Increased F-FDG uptake in the colon correlated with clinical symptoms but did not predict clinical outcome to ipilimumab.
自身免疫性结肠炎是接受伊匹木单抗治疗的患者中一种典型且可能严重的副作用。我们前瞻性地纳入了100例接受伊匹木单抗治疗的转移性黑色素瘤患者，进行氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描（F-FDG PET-CT）的影像学研究。全结肠炎的PET证据（“PET结肠炎”）与临床变量相关。我们观察到PET结肠炎与具有临床意义的腹泻之间存在显著相关性，尽管PET结肠炎更为常见（分别为49%和29%的患者）。PET结肠炎和腹泻均与治疗反应无显著相关性。然而，其他免疫相关不良事件，如垂体炎和肝炎与治疗反应及总生存期相关。结肠中F-FDG摄取增加与临床症状相关，但不能预测伊匹木单抗的临床结局。
