Liang Norah E, Wisneski Andrew D, Wang Sue X, Shunk Kendrick A, Wozniak Curtis J, Yang Joseph, Zimmet Jeffrey M, Ge Liang, Tseng Elaine E
San Francisco VA Medical Center, 4150 Clement St., 112D, San Francisco, CA 94121 USA.
J Invasive Cardiol. 2019 Aug;31(8):217-222. Epub 2019 May 15.
Aortic valve disease is prevalent in the veteran population. Transcatheter aortic valve replacement (TAVR) and minimally invasive surgical aortic valve replacement (MIAVR) are minimally invasive approaches predominantly performed at higher-volume cardiac centers. The study aim was to evaluate our experience with minimally invasive techniques at a Veterans Affairs Medical Center (VAMC), since outcomes from lower-volume federal facilities are relatively unknown.
This study examined retrospective data from 228 consecutive patients who underwent treatment for isolated aortic valve disease with MIAVR or TAVR via intent-to-treat at a VAMC between January 2011 and July 2017. Perioperative outcomes were analyzed using Stata version 15.
Operative mortality was 1.1% for MIAVR and 0.7% for TAVR (Χ² P=.79). Median length of hospital stay was 10 days (interquartile range [IQR], 7-14 days) for MIAVR and 4 days for TAVR (IQR, 3-6 days; Mann-Whitney P<.001). Postoperative new-onset atrial fibrillation occurred in 52% of MIAVR patients and 5.2% of TAVR patients (Χ² P<.001). Stroke occurred in 2.2% of MIAVR patients and 3.0% of TAVR patients (Χ² P=.71). In patients who underwent MIAVR, 5.4% required placement of a permanent pacemaker postoperatively, compared with 14% of TAVR patients (Χ² P=.04). Mild paravalvular leak (PVL) affected 2.2% of MIAVR and 28% of TAVR patients, with moderate PVL reported in 2.2% of MIAVR and 3% of TAVR patients (Χ² P<.001).
The VAMC heart team offers MIAVR and TAVR to veterans with isolated aortic valve disease, and has achieved excellent outcomes despite relatively lower case volumes. Both offer excellent hemodynamic results, with low mortality in a complex population.
主动脉瓣疾病在退伍军人中很常见。经导管主动脉瓣置换术(TAVR)和微创外科主动脉瓣置换术(MIAVR)是主要在高容量心脏中心进行的微创方法。本研究的目的是评估我们在退伍军人事务医疗中心(VAMC)采用微创技术的经验,因为来自低容量联邦机构的结果相对未知。
本研究检查了2011年1月至2017年7月期间在VAMC接受意向性治疗的228例连续接受孤立性主动脉瓣疾病MIAVR或TAVR治疗的患者的回顾性数据。使用Stata 15版分析围手术期结果。
MIAVR的手术死亡率为1.1%,TAVR为0.7%(Χ² P = 0.79)。MIAVR的中位住院时间为10天(四分位间距[IQR],7 - 14天),TAVR为4天(IQR,3 - 6天;Mann-Whitney P < 0.001)。52%的MIAVR患者和5.2%的TAVR患者术后发生新发房颤(Χ² P < 0.001)。2.2%的MIAVR患者和3.0%的TAVR患者发生中风(Χ² P = 0.71)。在接受MIAVR的患者中,5.4%术后需要植入永久性起搏器,而TAVR患者为14%(Χ² P = 0.04)。轻度瓣周漏(PVL)影响2.2%的MIAVR患者和28%的TAVR患者,中度PVL在2.2%的MIAVR患者和3%的TAVR患者中报告(Χ² P < 0.001)。
VAMC心脏团队为患有孤立性主动脉瓣疾病的退伍军人提供MIAVR和TAVR,尽管病例数量相对较少,但取得了优异的结果。两者均提供出色的血流动力学结果,在复杂人群中的死亡率较低。