Cakirca M, Dae S A, Zorlu M, Kiskac M, Tunc M, Karatoprak C
Department of Internal Medicine Clinic, Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey.
Niger J Clin Pract. 2019 May;22(5):713-717. doi: 10.4103/njcp.njcp_616_18.
To date, there have been no studies investigating whether or not there is a correlation between the serum endocan level and the atherosclerotic cardiovascular disease (ASCVD) risk score that is frequently used in the determination of the risk of cardiovascular disease. If a single parameter such as endocan can provide reliable results which could be used in the prediction of the cardiovascular disease risk, the workload of the clinician would be lightened. The aim of this study was to investigate whether or not there is an association between the serum endocan level and the ASVCD risk score.
This prospective, cross-sectional study included individuals age 40-79 years with risk factors calculated using the ASVCD score and individuals without any of those risk factors. In accordance with ASCVD risk calculation, each participant was questioned with respect to age, gender, height, weight, and lifestyle habits such as smoking, diseases, and medications. Systolic blood pressure, diastolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and serum endocan levels were measured and recorded. The serum endocan levels and ASCVD scores were compared.
The study included 205 individuals, comprising 92 (44.9%) males and 113 (55.1%) females with a mean age of 50.7 ± 7.6 years. The 10-year atherosclerosis risk was determined as mean 6.32% ± 5.9% (range, 0.3%-27.3%). The mean serum endocan level was calculated as 1109.6 ± 1479.7 ng/mL. As the ASCVD risk score increased, no increase was detected in the serum endocan level.
The results of the study suggested that the serum endocan level is not suitable for use in place of the ASCVD risk score as a predictor of cardiovascular disease risk.
迄今为止，尚无研究探讨血清内脂素水平与常用于确定心血管疾病风险的动脉粥样硬化性心血管疾病（ASCVD）风险评分之间是否存在相关性。如果像内脂素这样的单一参数能够提供可用于预测心血管疾病风险的可靠结果，那么临床医生的工作量将会减轻。本研究的目的是调查血清内脂素水平与ASVCD风险评分之间是否存在关联。
这项前瞻性横断面研究纳入了年龄在40 - 79岁、使用ASVCD评分计算风险因素的个体以及没有任何这些风险因素的个体。根据ASCVD风险计算，对每位参与者询问年龄、性别、身高、体重以及吸烟、疾病和用药等生活习惯。测量并记录收缩压、舒张压、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和血清内脂素水平。比较血清内脂素水平和ASCVD评分。
该研究纳入了205名个体，其中男性92名（44.9%），女性113名（55.1%），平均年龄为50.7±7.6岁。10年动脉粥样硬化风险确定为平均6.32%±5.9%（范围为0.3% - 27.3%）。血清内脂素平均水平计算为1109.6±1479.7 ng/mL。随着ASCVD风险评分增加，未检测到血清内脂素水平升高。
该研究结果表明，血清内脂素水平不适用于替代ASCVD风险评分作为心血管疾病风险的预测指标。
