Department of Neurology, Taizhou Hospital, Wenzhou Medical University, Zhejiang, China.
Clin Chim Acta. 2018 Mar;478:157-161. doi: 10.1016/j.cca.2017.12.040. Epub 2017 Dec 27.
Accumulating evidence has suggested that endocan and endoglin may play important roles in cardiovascular disease. However, no previous study has focused on these circulating levels in patients with large-artery atherosclerotic (LAA) stroke.
Serum levels of endocan and endoglin in 114 patients with LAA stroke and 114 age- and sex-matched controls were measured by ELISA. Serum samples from patients were available on day 1, day 6 and in the 4th week after ischaemic stroke(IS). Stroke severity was determined based on the NIHSS score and the stroke volume. An unfavourable outcome was defined as a mRS score>2 on day 90 after IS.
The endocan levels were significantly higher in patients with LAA stroke compared with the controls (p=0.001), and after adjustment for other factors (p=0.001). In addition, higher endocan levels were independently associated with unfavourable outcomes on both day 1 and day 6 after IS (p=0.018 and p=0.011). Endoglin levels were decreased on day 6 (p=0.002) and then recovered in the 4th week after IS. No correlation was found between endocan or endoglin and stroke severity.
Endocan levels are higher in patients with LAA stroke and can help in predicting the short-term unfavourable outcome. Endoglin levels are changed after stroke.
越来越多的证据表明，内皮细胞蛋白 C 受体（endocan）和内皮下层糖蛋白 1（endoglin）可能在心血管疾病中发挥重要作用。然而，之前的研究并未关注大动脉粥样硬化性（LAA）卒中患者的这些循环水平。
通过 ELISA 法检测 114 例 LAA 卒中患者和 114 例年龄和性别匹配的对照者的血清 endocan 和 endoglin 水平。患者的血清样本可在缺血性卒中（IS）后第 1 天、第 6 天和第 4 周获得。卒中严重程度根据 NIHSS 评分和卒中体积确定。不良结局定义为 IS 后第 90 天 mRS 评分>2。
与对照组相比，LAA 卒中患者的 endocan 水平显著升高（p=0.001），且在调整其他因素后（p=0.001）仍如此。此外，较高的 endocan 水平与 IS 后第 1 天和第 6 天的不良结局独立相关（p=0.018 和 p=0.011）。endoglin 水平在第 6 天下降（p=0.002），然后在 IS 后第 4 周恢复。未发现 endocan 或 endoglin 与卒中严重程度之间存在相关性。
LAA 卒中患者的 endocan 水平较高，有助于预测短期不良结局。endoglin 水平在卒中后发生变化。
