Ranneh Yazan, Hamsho Mohammed, Shkorfu Wijdan, Terzi Merve, Fadel Abdulmannan
Department of Nutrition and Dietetics, College of Pharmacy, Al-Ain University, Abu-Dhabi P.O. Box 64141, United Arab Emirates.
Department of Nutrition and Dietetics, Faculty of Health Science, Istanbul Yeni Yüzyıl University, Istanbul 34010, Turkey.
Nutrients. 2025 Jul 25;17(15):2436. doi: 10.3390/nu17152436.
Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder characterized by excess body weight, hyperandrogenism, hyperglycemia, and insulin resistance often resulting in hirsutism and infertility. Dietary strategies have been shown to ameliorate metabolic disturbances, hormonal imbalances, and inflammation associated with PCOS. Recent evidence indicates that intermittent fasting (IF) could effectively enhance health outcomes and regulate circadian rhythm; however, its impact on PCOS remain unclear.
Therefore, this systematic review and meta-analysis aims to examine the effect of IF on women diagnosed with PCOS.
Comprehensive research was conducted across three major databases including PubMed, Scopus, and Web of Science without date restrictions. Meta-analysis was performed using Cochrane Review Manager Version 5.4 software.
Five studies fulfilled the inclusion criteria. IF significantly reduced body weight (MD = -4.25 kg, 95% CI: -7.71, -0.79; = 0.02), BMI (MD = -2.05 kg/m, 95% CI: -3.26, -0.85; = 0.0008), fasting blood glucose (FBG; MD = -2.86 mg/dL, 95% CI: -4.83, -0.89; = 0.004), fasting blood insulin (FBI; MD = -3.17 μU/mL, 95% CI: -5.18, -1.16; = 0.002), insulin resistance (HOMA-IR; MD = -0.94, 95% CI: -1.39, -0.50; < 0.0001), triglycerides (TG; MD = -40.71 mg/dL, 95% CI: -61.53, -19.90; = 0.0001), dehydroepiandrosterone sulfate (DHEA-S; MD = -33.21 μg/dL, 95% CI: -57.29, -9.13; = 0.007), free androgen index (FAI; MD = -1.61%, 95% CI: -2.76, -0.45; = 0.006), and C-reactive protein (CRP; MD = -2.00 mg/L, 95% CI: -3.15, -0.85; = 0.006), while increasing sex hormone-binding globulin (SHBG; SMD = 0.50, 95% CI: 0.22, 0.77; = 0.004). No significant changes were observed in waist-to-hip ratio (WHR), total cholesterol (TC), LDL, HDL, total testosterone (TT), or anti-Mullerian hormone (AMH).
IF represents a promising strategy for improving weight and metabolic, hormonal, and inflammatory profiles in women with PCOS. However, the existing evidence remains preliminary, necessitating further robust studies to substantiate these findings.
多囊卵巢综合征（PCOS）是一种常见的内分泌紊乱疾病，其特征为体重超标、雄激素过多、高血糖和胰岛素抵抗，常导致多毛症和不孕。饮食策略已被证明可改善与PCOS相关的代谢紊乱、激素失衡和炎症。最近的证据表明，间歇性禁食（IF）可有效改善健康状况并调节昼夜节律；然而，其对PCOS的影响仍不明确。
因此，本系统评价和荟萃分析旨在研究IF对诊断为PCOS的女性的影响。
在包括PubMed、Scopus和Web of Science在内的三个主要数据库中进行了无日期限制的全面研究。使用Cochrane系统评价管理软件5.4版进行荟萃分析。
五项研究符合纳入标准。IF显著降低了体重（MD = -4.25 kg，95%CI：-7.71，-0.79；P = 0.02）、体重指数（MD = -2.05 kg/m²，95%CI：-3.26，-0.85；P = 0.0008）、空腹血糖（FBG；MD = -2.86 mg/dL，95%CI：-4.83，-0.89；P = 0.004）、空腹血胰岛素（FBI；MD = -3.17 μU/mL，95%CI：-5.18，-1.16；P = 0.002）、胰岛素抵抗（HOMA-IR；MD = -0.94，95%CI：-1.39，-0.50；P < 0.0001）、甘油三酯（TG；MD = -40.71 mg/dL，95%CI：-61.53，-19.90；P = 0.0001）、硫酸脱氢表雄酮（DHEA-S；MD = -33.21 μg/dL，95%CI：-57.29，-9.13；P = 0.007）、游离雄激素指数（FAI；MD = -1.61%，95%CI：-2.76，-0.45；P = 0.006）和C反应蛋白（CRP；MD = -2.00 mg/L，95%CI：-3.15，-0.85；P = 0.006），同时增加了性激素结合球蛋白（SHBG；SMD = 0.50，95%CI：0.22，0.77；P = 0.004）。腰臀比（WHR）、总胆固醇（TC）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、总睾酮（TT）或抗苗勒管激素（AMH）未见显著变化。
IF是改善PCOS女性体重及代谢、激素和炎症指标的一种有前景的策略。然而，现有证据仍属初步，需要进一步的有力研究来证实这些发现。
