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阿根廷与进行性萎缩性鼻炎和猪肺炎病例相关菌株的特性分析与比较。

Characterization and comparison of strains of associated with cases of progressive atrophic rhinitis and porcine pneumonia in Argentina.

作者信息

Bessone Fernando A, Pérez Maria Laura Soriano, Zielinski Gustavo, Dibarbora Marina, Conde M B, Cappuccio Javier, Alustiza Fabrisio

机构信息

Department of Animal Health, Instituto Nacional de Tecnología Agropecuaria, Estación Experimental Agropecuaria Marcos Juárez, Marcos Juárez, Córdoba, Argentina.

CONICET, Buenos Aires, Argentina.

出版信息

Vet World. 2019;12(3):434-439. doi: 10.14202/vetworld.2019.434-439. Epub 2019 Mar 21.

DOI:10.14202/vetworld.2019.434-439
PMID:31089314
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6487256/
Abstract

BACKGROUND

(Pm) is the causative agent of progressive atrophic rhinitis (PAR) and pneumonic pasteurellosis (PN) in pigs. Pm is a member of the porcine respiratory complex responsible for important economic loss in the pig industry.

AIM

This study aimed to characterize the Pm strains recovered from clinical cases of PN and PAR and to elucidate the antibiotic susceptibility profiles of the strains.

MATERIALS AND METHODS

Sixty strains were characterized molecularly by polymerase chain reaction to determine species-specific gene, capsular type (A or D), and toxin A production. The agar diffusion method was employed to evaluate antibiotic resistance profiles.

RESULTS

We found that 65% of strains belonged to capsular type A or D, and 15% of those were positive to gene. The antibiotic susceptibility profiles found were sensitive in decreasing order to: Enrofloxacin, ceftiofur (CTF), ampicillin, tilmicosin (TIL), florfenicol (FFN), spectinomycin (SPC), gentamicin, oxytetracycline (OTC), and trimethoprim-sulfamethoxazole (TMS). Strains were resistant in decreasing order to: Lincomycin (LIN), tylosin (TYL), erythromycin (ERY), TMS, SPC, OTC, FFN, TIL, and CTF.

CONCLUSION

The gene was detected in many Pm isolates from pneumonic lungs. Capsule type A or D was the most frequently found among the collected isolates. LIN, TYL, and ERY are the drugs which showed higher percentages of resistant isolates.

摘要

背景

多杀性巴氏杆菌（Pm）是猪进行性萎缩性鼻炎（PAR）和猪肺疫（PN）的病原体。Pm是猪呼吸道菌群的成员之一，给养猪业造成了重大经济损失。

目的

本研究旨在鉴定从PN和PAR临床病例中分离出的Pm菌株，并阐明这些菌株的抗生素敏感性谱。

材料与方法

采用聚合酶链反应对60株菌株进行分子鉴定，以确定种特异性基因、荚膜类型（A或D）和毒素A的产生情况。采用琼脂扩散法评估抗生素耐药谱。

结果

我们发现65%的菌株属于A或D荚膜型，其中15%的菌株对特定基因呈阳性。所发现的抗生素敏感性谱从高到低依次为：恩诺沙星、头孢噻呋（CTF）、氨苄西林、替米考星（TIL）、氟苯尼考（FFN）、壮观霉素（SPC）、庆大霉素、土霉素（OTC）和甲氧苄啶-磺胺甲恶唑（TMS）。菌株耐药性从高到低依次为：林可霉素（LIN）、泰乐菌素（TYL）、红霉素（ERY）、TMS、SPC、OTC、FFN、TIL和CTF。

结论

在许多来自肺炎肺脏的Pm分离株中检测到特定基因。收集的分离株中最常见的荚膜类型为A或D型。LIN、TYL和ERY是耐药分离株比例较高的药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6be3/6487256/8fd78e145a2e/Vetworld-12-434-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6be3/6487256/1f702c2aad0b/Vetworld-12-434-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6be3/6487256/dde603a08f1a/Vetworld-12-434-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6be3/6487256/8fd78e145a2e/Vetworld-12-434-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6be3/6487256/1f702c2aad0b/Vetworld-12-434-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6be3/6487256/dde603a08f1a/Vetworld-12-434-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6be3/6487256/8fd78e145a2e/Vetworld-12-434-g003.jpg

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