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使用FeO@SiO纳米复合材料中功能化氧化石墨烯纳米片修饰的石墨丝网印刷电极伏安法测定对乙酰氨基酚和色氨酸。

Voltammetric Determination of Acetaminophen and Tryptophan Using a Graphite Screen Printed Electrode Modified with Functionalized Graphene Oxide Nanosheets Within a FeO@SiO Nanocomposite.

作者信息

Beitollahi Hadi, Garkani-Nejad Fariba, Tajik Somayeh, Ganjali Mohammad Reza

机构信息

Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.

Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran.

出版信息

Iran J Pharm Res. 2019 Winter;18(1):80-90.

PMID:31089346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6487427/
Abstract

A high sensitive electrochemical nanostructure sensor based on graphene oxide/FeO@SiO nanocomposite modified graphite screen printed electrode (GO/FeO@SiO/SPE) has been developed for trace analysis of acetaminophen. The electrochemical study of the modified electrode, as well as its efficiency for simultaneous voltammetric oxidation of acetaminophen and tryptophan is described. Compared with bare SPE the GO/FeO@SiO/SPE exhibited excellent electrocatalytic activity toward the oxidation of acetaminophen. The plot of catalytic current versus acetaminophen concentration showed a linear segment in the concentration range 0.5 to 100.0 µM. The detection limit of 0.1 µM was obtained using calibration plot. Also the anodic peaks of acetaminophen and tryptophan in their mixture can be well separated. The GO/FeO@SiO/SPE has been successfully applied and validated by analyzing acetaminophen and tryptophan in urine and pharmaceutical samples.

摘要

基于氧化石墨烯/FeO@SiO纳米复合材料修饰石墨丝网印刷电极（GO/FeO@SiO/SPE）开发了一种高灵敏度电化学纳米结构传感器，用于对乙酰氨基酚进行痕量分析。描述了修饰电极的电化学研究及其对乙酰氨基酚和色氨酸同时进行伏安氧化的效率。与裸SPE相比，GO/FeO@SiO/SPE对乙酰氨基酚的氧化表现出优异的电催化活性。催化电流与乙酰氨基酚浓度的曲线在0.5至100.0μM的浓度范围内呈线性段。使用校准曲线获得的检测限为0.1μM。此外，乙酰氨基酚和色氨酸混合物中的阳极峰可以很好地分离。GO/FeO@SiO/SPE已通过分析尿液和药物样品中的乙酰氨基酚和色氨酸成功应用并得到验证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1cc/6487427/a5b86378d0f3/ijpr-18-080-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1cc/6487427/7b3e0ea28637/ijpr-18-080-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1cc/6487427/19eb64c8ef87/ijpr-18-080-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1cc/6487427/0b76a0088d1e/ijpr-18-080-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1cc/6487427/69ea50231fb3/ijpr-18-080-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1cc/6487427/1ca52994ee51/ijpr-18-080-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1cc/6487427/5e8440501417/ijpr-18-080-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1cc/6487427/a5b86378d0f3/ijpr-18-080-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1cc/6487427/7b3e0ea28637/ijpr-18-080-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1cc/6487427/19eb64c8ef87/ijpr-18-080-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1cc/6487427/0b76a0088d1e/ijpr-18-080-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1cc/6487427/69ea50231fb3/ijpr-18-080-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1cc/6487427/1ca52994ee51/ijpr-18-080-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1cc/6487427/5e8440501417/ijpr-18-080-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1cc/6487427/a5b86378d0f3/ijpr-18-080-g007.jpg

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