Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia.
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida.
Microcirculation. 2019 Nov;26(8):e12558. doi: 10.1111/micc.12558.
Historically, major advances in microvascular research have been made by integrating physiology and bioengineering approaches. This Special Topics Issue focuses on providing a spotlight on emerging areas of microvascular research, showcasing how interdisciplinary collaborations and application of novel techniques can impact our understanding of tissue-specific microvascular remodeling by integrating cell behaviors across scales. The authors in this issue investigate pericyte physiology, perturbations to uteroplacental blood flow, bone microvascular alterations in aging, molecular markers of revascularization, and microfluidic devices to mimic the lymphatic system. The articles highlight the continued importance of expanding our understanding of the microvascular system in health, and disease extends microvascular boundaries in the face of current paradigms, and illustrates how emerging leaders in the field are creating new scientific niches.
从历史上看，通过整合生理学和生物工程方法，微血管研究取得了重大进展。本特刊重点介绍了微血管研究新兴领域的研究成果，展示了跨尺度整合细胞行为的跨学科合作和新技术的应用如何影响我们对组织特异性微血管重塑的理解。本期特刊的作者研究了周细胞生理学、子宫胎盘血流紊乱、衰老中的骨微血管改变、再血管化的分子标志物以及模拟淋巴系统的微流控装置。这些文章强调了在当前范式下扩展我们对健康和疾病中微血管系统的理解的持续重要性，扩展了微血管的边界，并说明了该领域的新兴领导者如何创造新的科学领域。
