Neumann R, Aberer E, Stanek G
Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Feb;263(3):372-6. doi: 10.1016/s0176-6724(87)80095-0.
72 patients with Erythema chronicum migrans were treated with phenoxymethyl penicillin, 1,5 mill. IU p.o. three times a day for 14 days. Two children got the same therapy, but in a dosage of 400,000 IU three times a day for 10 days. In three of 15 skin samples, taken from the periphery of ECM lesions, spirochetal organisms were isolated. Of the 72 patients 16 had raised IgG (greater than or equal to 128) and 9 had raised IgM (greater than or equal to 64) titers to Borrelia burgdorferi. Under treatment with phenoxymethyl penicillin (penicillin V) all ECM lesions resolved within 6 to 10 days. After an observation period of 9 to 14 months no major or minor late manifestations of Lyme disease have developed in any of the 72 patients.
72例慢性游走性红斑患者接受了苯氧甲基青霉素治疗，口服150万国际单位，每日3次，共14天。两名儿童接受了相同的治疗，但剂量为每日40万国际单位，共10天。从慢性游走性红斑病变边缘采集的15份皮肤样本中，有3份分离出了螺旋体生物。72例患者中，16例抗伯氏疏螺旋体IgG升高（大于或等于128），9例抗伯氏疏螺旋体IgM升高（大于或等于64）。在用苯氧甲基青霉素（青霉素V）治疗后，所有慢性游走性红斑病变在6至10天内消退。在9至14个月的观察期后，72例患者中无一例出现莱姆病的任何严重或轻微晚期表现。
