Berger B W
J Am Acad Dermatol. 1986 Sep;15(3):459-63. doi: 10.1016/s0190-9622(86)70194-1.
The efficacy of antibiotic treatment of 117 patients with erythema chronicum migrans of Lyme disease was evaluated in terms of the necessity for retreatment and the prevention of the late manifestations of Lyme disease. Fifty-six patients with a minor form of the illness did not require retreatment and did not develop late manifestations following antibiotic treatment. Three pregnant patients were included in this group. Fourteen of sixty-one patients with a major form of the illness required retreatment, and five developed posttreatment late manifestations of Lyme disease consisting of Bell's palsy and persistent joint pain. Although the preferred antibiotic for treating erythema chronicum migrans of Lyme disease has not been conclusively established, tetracycline and penicillin proved effective. The use of probenecid plus penicillin may be of benefit to patients with the major form of the illness.
通过再次治疗的必要性以及莱姆病晚期表现的预防情况，对117例莱姆病慢性游走性红斑患者的抗生素治疗效果进行了评估。56例轻症患者无需再次治疗，抗生素治疗后也未出现晚期表现。该组包括3例孕妇。61例重症患者中有14例需要再次治疗，5例出现了莱姆病治疗后的晚期表现，包括贝尔氏面瘫和持续性关节疼痛。虽然治疗莱姆病慢性游走性红斑的首选抗生素尚未最终确定，但四环素和青霉素已证明有效。丙磺舒加青霉素的联合使用可能对重症患者有益。
