微小RNA-183-5p：前列腺癌的一种新的潜在标志物。
MicroRNA-183-5p: A New Potential Marker for Prostate Cancer.
作者信息
Waseem Mohammad, Ahmad Mohammad Kaleem, Serajuddin Mohammad, Bhaskar Ved, Sankhwar Satya Narain, Mahdi Abbas Ali
机构信息
1Molecular and Cell Biology, Department of Biochemistry, King George's Medical University, Lucknow, U.P. 226003 India.
3Department of Zoology, Lucknow University, Lucknow, U.P. 226007 India.
出版信息
Indian J Clin Biochem. 2019 Apr;34(2):207-212. doi: 10.1007/s12291-017-0731-9. Epub 2017 Dec 29.
The microRNA (miR)-183-5p is expressed at high level in the majority of cancer. The purpose of present study was to investigate the role of oncogenic miR-183-5p in prostate cancer (PCa) as biomarker. We carried out our experiment in 50 prostate cancer patients and 40 patients of benign prostatic hyperplasia (BPH) and 40 adjacent controls tissue. The expression of miR-183-5p was evaluated through reverse transcription qualitative polymerase chain reaction. We found that the expression of miR-183-5p in PCa tissue was significantly up regulated as compared to BPH patients and adjacent normal tissues as control. Additionally, miR-183 expression was correlated with higher prostate-specific antigen, higher Gleason Score and metastatic condition. A receiver operating characteristic curve analysis revealed that miR-183-5p distinguished PCa patients from BPH patients and also from control. In conclusion, our data suggest that oncogenic miR-183-5p may be useful as a new tissue specific diagnostic biomarker in prostate cancer.
微小RNA（miR）-183-5p在大多数癌症中高表达。本研究的目的是探讨致癌性miR-183-5p在前列腺癌（PCa）中作为生物标志物的作用。我们对50例前列腺癌患者、40例良性前列腺增生（BPH）患者和40例相邻对照组织进行了实验。通过逆转录定性聚合酶链反应评估miR-183-5p的表达。我们发现，与BPH患者和作为对照的相邻正常组织相比，PCa组织中miR-183-5p的表达显著上调。此外，miR-183的表达与较高的前列腺特异性抗原、较高的 Gleason评分和转移情况相关。受试者工作特征曲线分析显示，miR-183-5p可区分PCa患者与BPH患者以及对照。总之，我们的数据表明，致癌性miR-183-5p可能作为前列腺癌一种新的组织特异性诊断生物标志物。
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