人乳头瘤病毒驱动的口咽癌：分子生物学与致癌机制的当前认知
HPV-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis.
作者信息
Pan Cassie, Issaeva Natalia, Yarbrough Wendell G
机构信息
1Department of Surgery, Division of Otolaryngology, Yale University, New Haven, CT USA.
2Department of Otolaryngology/Head and Neck Surgery; Lineberger Cancer Center, University of North Carolina at Chapel Hill, 170 Manning Drive, Campus Box 7070, Chapel Hill, NC 27599 USA.
出版信息
Cancers Head Neck. 2018 Dec 29;3:12. doi: 10.1186/s41199-018-0039-3. eCollection 2018.
Abstract
Understanding of oropharyngeal squamous cell carcinoma has significantly progressed over the last decades, and the concept that this disease can be subdivided into two distinct entities based on human papilloma virus (HPV) status has gained acceptance. To combat the constantly growing epidemic of HPV+ oropharyngeal cancer, further investigation and characterization the unique features of the disease, along with the development and implementation of new, targeted therapies, is crucial. In this review, we summarize the etiology, pathogenesis, diagnosis, treatment, and molecular characteristics of HPV-associated oropharyngeal squamous cell carcinoma.
摘要
在过去几十年里，人们对口腔鳞状细胞癌的认识有了显著进展，并且基于人乳头瘤病毒（HPV）状态将这种疾病细分为两种不同类型的概念已被广泛接受。为了应对HPV阳性口咽癌不断增长的流行趋势，进一步研究和描述该疾病的独特特征，以及开发和实施新的靶向治疗方法至关重要。在这篇综述中，我们总结了HPV相关口腔鳞状细胞癌的病因、发病机制、诊断、治疗及分子特征。
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本文引用的文献
1
Advances in biomarkers and treatment strategies for HPV-associated head and neck cancer.
Oncoscience. 2018 Jun 25;5(5-6):140-141. doi: 10.18632/oncoscience.425. eCollection 2018 May.
2
Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers.
Cancer Res. 2018 Aug 15;78(16):4613-4626. doi: 10.1158/0008-5472.CAN-17-0642. Epub 2018 Jun 19.
3
Human papillomavirus prevalence in a Mid-European oral squamous cell cancer population: A cohort study.
Oral Dis. 2018 Sep;24(6):948-956. doi: 10.1111/odi.12882. Epub 2018 Jun 8.
4
New developments in the management of head and neck cancer - impact of pembrolizumab.
Ther Clin Risk Manag. 2018 Feb 19;14:295-303. doi: 10.2147/TCRM.S125059. eCollection 2018.
5
Meta analysis: HPV and p16 pattern determines survival in patients with HNSCC and identifies potential new biologic subtype.
Sci Rep. 2017 Dec 1;7(1):16715. doi: 10.1038/s41598-017-16918-w.
6
Effect of Prophylactic Human Papillomavirus (HPV) Vaccination on Oral HPV Infections Among Young Adults in the United States.
J Clin Oncol. 2018 Jan 20;36(3):262-267. doi: 10.1200/JCO.2017.75.0141. Epub 2017 Nov 28.
7
HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers.
Mol Cancer Res. 2018 Jan;16(1):90-102. doi: 10.1158/1541-7786.MCR-17-0153. Epub 2017 Sep 19.
8
Demethylation Therapy as a Targeted Treatment for Human Papillomavirus-Associated Head and Neck Cancer.
Clin Cancer Res. 2017 Dec 1;23(23):7276-7287. doi: 10.1158/1078-0432.CCR-17-1438. Epub 2017 Sep 15.
9
Nonuniform Distribution of High-risk Human Papillomavirus in Squamous Cell Carcinomas of the Oropharynx: Rethinking the Anatomic Boundaries of Oral and Oropharyngeal Carcinoma From an Oncologic HPV Perspective.
Am J Surg Pathol. 2017 Dec;41(12):1722-1728. doi: 10.1097/PAS.0000000000000929.
10
Integration of Human Papillomavirus Genomes in Head and Neck Cancer: Is It Time to Consider a Paradigm Shift?
Viruses. 2017 Aug 3;9(8):208. doi: 10.3390/v9080208.
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