Pan Cassie, Issaeva Natalia, Yarbrough Wendell G
1Department of Surgery, Division of Otolaryngology, Yale University, New Haven, CT USA.
2Department of Otolaryngology/Head and Neck Surgery; Lineberger Cancer Center, University of North Carolina at Chapel Hill, 170 Manning Drive, Campus Box 7070, Chapel Hill, NC 27599 USA.
Cancers Head Neck. 2018 Dec 29;3:12. doi: 10.1186/s41199-018-0039-3. eCollection 2018.
Understanding of oropharyngeal squamous cell carcinoma has significantly progressed over the last decades, and the concept that this disease can be subdivided into two distinct entities based on human papilloma virus (HPV) status has gained acceptance. To combat the constantly growing epidemic of HPV+ oropharyngeal cancer, further investigation and characterization the unique features of the disease, along with the development and implementation of new, targeted therapies, is crucial. In this review, we summarize the etiology, pathogenesis, diagnosis, treatment, and molecular characteristics of HPV-associated oropharyngeal squamous cell carcinoma.
在过去几十年里，人们对口腔鳞状细胞癌的认识有了显著进展，并且基于人乳头瘤病毒（HPV）状态将这种疾病细分为两种不同类型的概念已被广泛接受。为了应对HPV阳性口咽癌不断增长的流行趋势，进一步研究和描述该疾病的独特特征，以及开发和实施新的靶向治疗方法至关重要。在这篇综述中，我们总结了HPV相关口腔鳞状细胞癌的病因、发病机制、诊断、治疗及分子特征。
