Sethi Sneha, Shahin Alana, Rahim Intisar Nuha Abd
Australian Research Center for Population Oral Health, Adelaide Dental School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA 5000 Australia.
Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA Australia.
Indian J Otolaryngol Head Neck Surg. 2024 Feb;76(1):268-276. doi: 10.1007/s12070-023-04140-2. Epub 2023 Aug 29.
Vaccinations have shown a decrease in human papillomavirus (HPV) infection-related cervical cancer in women, but there has been a sharp rise in the HPV infection-related oropharyngeal cancer cases over the past few decades. Recent studies have suggested the association of HPV infections with tonsillar cancers as well and suggestions regarding preventive tonsillectomies in order to achieve a decrease in HPV infection-related oropharyngeal or tonsillar cancer have arisen. However, there is limited cumulative evidence validated at a global level to support the endorsement of this strategy. This research revolves around the concept of burden of tonsillar carcinomas due to oropharyngeal HPV infection. Thus, a systematic review and meta-analysis of existing studies was undertaken to estimate the pooled prevalence of tonsillar cancer associated with oropharyngeal HPV infection. Published articles on tonsillar cancer with and without HPV infection from PubMed, Embase, Scopus and Web of Science were systematically searched from inception until 23 December 2021. A random-effects model was used to estimate the pooled prevalence forest plots. The systematic review revealed that 50% of the reported cases of tonsillar cancer had an oropharyngeal HPV infection, questioning the preventive nature of an early tonsillectomy which is essentially an invasive surgical procedure. Large heterogeneity was reported in the included studies, and there was insufficient data for sub-group analysis. Future research and representative studies are required to thoroughly explore the correlation between HPV infection and tonsillar cancer.
The online version contains supplementary material available at 10.1007/s12070-023-04140-2.
疫苗接种已显示女性人乳头瘤病毒（HPV）感染相关宫颈癌有所减少，但在过去几十年中，HPV感染相关口咽癌病例急剧增加。最近的研究表明HPV感染也与扁桃体癌有关，并且出现了关于预防性扁桃体切除术以降低HPV感染相关口咽癌或扁桃体癌的建议。然而，在全球范围内得到验证以支持这一策略认可的累积证据有限。本研究围绕口咽HPV感染导致的扁桃体癌负担概念展开。因此，对现有研究进行了系统综述和荟萃分析，以估计与口咽HPV感染相关的扁桃体癌合并患病率。从创刊到2021年12月23日，系统检索了PubMed、Embase、Scopus和Web of Science上关于有或无HPV感染的扁桃体癌的已发表文章。使用随机效应模型估计合并患病率森林图。系统综述显示，报告的扁桃体癌病例中有50%存在口咽HPV感染，这对早期扁桃体切除术的预防性提出了质疑，因为这本质上是一种侵入性手术。纳入研究报告了较大的异质性，且亚组分析数据不足。需要未来的研究和代表性研究来彻底探索HPV感染与扁桃体癌之间的相关性。
在线版本包含可在10.1007/s12070-023-04140-2获取的补充材料。
