University Clinic of Craniomaxillofacial Surgery, Medical University Innsbruck, Innsbruck, Austria.
University Clinic of Prosthodontics, Medical University Innsbruck, Innsbruck, Austria.
Oral Dis. 2018 Sep;24(6):948-956. doi: 10.1111/odi.12882. Epub 2018 Jun 8.
Human papillomavirus infection has been investigated intensively regarding oropharyngeal carcinoma. However, there is still lack of knowledge about the impact of oral HPV infections concerning oral squamous cell carcinoma. This study investigates the prevalence of oral HPV infection in such patients, identifying possible differences between HPV+ and HPV- patients.
One hundred and six consequent patients were investigated. After completion of a study questionnaire regarding risk factors, a brush smear sample was taken in each subject to identify the individual oral HPV status (overall/low risk/high risk).
About 35.8% of the patients were tested positive for HPV in the oral cavity (14% low risk, 28.3% high risk). Patients with oral HPV infection and high-risk HPV infection were significantly younger (p < 0.001) and had a higher alcohol consumption (p = 0.0075 resp. p = 0.0022). A high number of different sexual partners were significantly correlated with any type of HPV infection. At last, patients with high-risk oral HPV infection had experienced more tooth extractions during their lifetime.
Oral HPV infections may influence the course of disease of oral squamous cell carcinoma as HPV+ patients are about 10 years younger. It seems that high alcohol consumption facilitates high-risk HPV infection. It may be presumed that both alcohol consumption and high-risk oral HPV infection act synergistically, explaining earlier cancer onset.
人乳头瘤病毒（HPV）感染与口咽癌的相关性已得到深入研究。然而，关于口腔 HPV 感染对口咽鳞状细胞癌的影响，我们仍知之甚少。本研究旨在调查此类患者中口腔 HPV 感染的流行情况，并确定 HPV+和 HPV-患者之间可能存在的差异。
共调查了 106 例连续患者。在完成有关危险因素的研究问卷后，每位患者均接受了口腔刷拭子样本采集，以确定个体的口腔 HPV 状态（总体/低危/高危）。
约 35.8%的患者口腔 HPV 检测呈阳性（14%为低危型，28.3%为高危型）。口腔 HPV 感染和高危 HPV 感染患者明显更年轻（p<0.001），且饮酒量更高（p=0.0075 及 p=0.0022）。性伴侣数量较多与任何类型的 HPV 感染均显著相关。最后，高危型口腔 HPV 感染患者一生中经历的拔牙次数更多。
口腔 HPV 感染可能影响口腔鳞状细胞癌的病程，HPV+患者比 HPV-患者年轻约 10 岁。高危型 HPV 感染似乎更容易受到高酒精摄入的影响。可以推测，高酒精摄入和高危型口腔 HPV 感染具有协同作用，从而导致癌症更早发生。
