Chuang Jeremy, Uche An, Gupta Rohan, Margolin Kim, Kim Phyllis
Department of Internal Medicine, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA.
Division of Hematology and Medical Oncology, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA.
Case Rep Oncol Med. 2019 Apr 9;2019:9246596. doi: 10.1155/2019/9246596. eCollection 2019.
Acute disseminated intravascular coagulation (DIC) is a pathological process involving dysfunction of the coagulation cascade. In this case report, we discuss a 33-year-old woman with BRAF V600E-mutated metastatic melanoma who presented in fulminant DIC with concurrent hemorrhagic and thrombotic manifestations and discuss the patient's brief response to combination therapy. In our discussion, we highlight the current understanding of DIC and also identify opportunities for future research to elucidate the genetic aberrations in melanoma that may result in treatment resistance to combination therapy.
急性弥散性血管内凝血（DIC）是一种涉及凝血级联功能障碍的病理过程。在本病例报告中，我们讨论了一名33岁的BRAF V600E突变转移性黑色素瘤女性患者，她以暴发性DIC伴出血和血栓形成表现就诊，并讨论了患者对联合治疗的短暂反应。在我们的讨论中，我们强调了目前对DIC的认识，同时也确定了未来研究的机会，以阐明黑色素瘤中可能导致联合治疗耐药的基因畸变。
