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[志贺毒素相关溶血尿毒综合征:如何预防?]

[Shiga-toxin associated hemolytic uremic syndrome: How to prevent it?].

作者信息

Cavagnaro Sm Felipe

机构信息

Clínica Alemana de Santiago, Facultad de Medicina, Universidad del Desarrollo, Chile.

出版信息

Rev Chil Pediatr. 2019 Apr;90(2):139-144. doi: 10.32641/rchped.v90i2.1044.

DOI:10.32641/rchped.v90i2.1044
PMID:31095229
Abstract

Hemolytic uremic syndrome (HUS) associated with intestinal infection by Shiga toxin-producing bacteria, which mainly affects children, can cause severe acute morbidity, chronic sequelae in seve ral organs, and premature death in some of them. Given its zoonotic nature, adequate measures of agricultural management and proper hygiene of what we consume are essential to prevent infection. Once the HUS is triggered, medical management is currently mainly supportive. In recent years, va rious therapeutic strategies have been developed to prevent this disease from occurring or, at least, to mitigate its morbidity and mortality consequences. This article describes specific actions at different levels of prevention of this pathology.

摘要

溶血性尿毒症综合征(HUS)与产志贺毒素细菌引起的肠道感染有关,主要影响儿童,可导致严重的急性发病、多个器官的慢性后遗症,部分患者还会过早死亡。鉴于其人畜共患的性质,采取适当的农业管理措施和注意所食用食物的卫生对于预防感染至关重要。一旦引发HUS,目前的医疗管理主要是支持性的。近年来,已开发出各种治疗策略来预防这种疾病的发生,或者至少减轻其发病和死亡后果。本文描述了针对这种病症在不同预防层面的具体行动。

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Characteristics of hemolytic uremic syndrome in patients from a pediatric hospital in Peru, 2010-2020.2010-2020 年秘鲁一家儿童医院溶血尿毒综合征患者的特征。
Rev Peru Med Exp Salud Publica. 2023 Apr-Jun;40(2):207-212. doi: 10.17843/rpmesp.2023.402.12708.
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Whole-Genome Phylogenetic Analysis Reveals a Wide Diversity of Non-O157 STEC Isolated From Ground Beef and Cattle Feces.全基因组系统发育分析揭示了从碎牛肉和牛粪中分离出的非O157 STEC的广泛多样性。
Front Microbiol. 2021 Jan 18;11:622663. doi: 10.3389/fmicb.2020.622663. eCollection 2020.
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Virulence Genes, Shiga Toxin Subtypes, Serogroups, and Clonal Relationship of Shiga Toxin-Producing Strains Isolated from Livestock and Companion Animals.
从家畜和伴侣动物中分离出的产志贺毒素菌株的毒力基因、志贺毒素亚型、血清群及克隆关系
Animals (Basel). 2019 Sep 27;9(10):733. doi: 10.3390/ani9100733.