Oliveira J S, Muccilo G, Scozzafave-Neto F, Maffia L G
Braz J Med Biol Res. 1986;19(3):367-74.
The effect of mild acute exercise (swimming for 1 h), restraint for 1 h and fasting for 48 h on myocardial norepinephrine concentration was compared with rats "at rest" using 320 control and chronically T. cruzi-infected rats at 50, 110, 200 and 380 days of age. Ventricular norepinephrine concentrations of control and similarly aged T. cruzi-infected rats were different for 2 of 4 "at rest" groups. Significant and opposite differences in ventricular norepinephrine were observed for restrained T. cruzi-infected rats when compared to controls (-35% in 50-day old rats and +40% in 110-day old rats). Exercised, "at rest" and fasted control rats presented a significant age-dependent decrease of ventricular norepinephrine concentration, which was not observed for restrained control rats. Norepinephrine levels of pooled atria from 120-day old "at rest" T. cruzi-infected rats were significantly lower than those from non-infected controls, whereas no difference was found in serotonin levels. The lability of myocardial norepinephrine levels in T. cruzi-infected rats suggests, but does not demonstrate, that there is a disturbance of the cardiac sympathetic control.
将轻度急性运动（游泳1小时）、束缚1小时和禁食48小时对心肌去甲肾上腺素浓度的影响，与“静息”状态下的大鼠进行了比较，使用了320只对照大鼠和50、110、200及380日龄慢性感染克氏锥虫的大鼠。在4个“静息”组中的2组，对照大鼠和年龄相仿的克氏锥虫感染大鼠的心室去甲肾上腺素浓度有所不同。与对照相比，束缚状态下的克氏锥虫感染大鼠心室去甲肾上腺素出现了显著且相反的差异（50日龄大鼠降低35%，110日龄大鼠升高40%）。运动、“静息”和禁食的对照大鼠心室去甲肾上腺素浓度呈现出显著的年龄依赖性降低，而束缚状态下的对照大鼠未观察到这种情况。120日龄“静息”的克氏锥虫感染大鼠合并心房的去甲肾上腺素水平显著低于未感染的对照大鼠，而血清素水平未发现差异。克氏锥虫感染大鼠心肌去甲肾上腺素水平的不稳定性表明（但未证实）存在心脏交感神经控制的紊乱。
