School of Computing, University of Leeds, Leeds, United Kingdom.
School of Pathology, Stanford University, Palo Alto, California, United States of America.
PLoS Comput Biol. 2019 May 16;15(5):e1006958. doi: 10.1371/journal.pcbi.1006958. eCollection 2019 May.
Improvements in technology often drive scientific discovery. Therefore, research requires sustained investment in the latest equipment and training for the researchers who are going to use it. Prioritising and administering infrastructure investment is challenging because future needs are difficult to predict. In the past, highly computationally demanding research was associated primarily with particle physics and astronomy experiments. However, as biology becomes more quantitative and bioscientists generate more and more data, their computational requirements may ultimately exceed those of physical scientists. Computation has always been central to bioinformatics, but now imaging experiments have rapidly growing data processing and storage requirements. There is also an urgent need for new modelling and simulation tools to provide insight and understanding of these biophysical experiments. Bioscience communities must work together to provide the software and skills training needed in their areas. Research-active institutions need to recognise that computation is now vital in many more areas of discovery and create an environment where it can be embraced. The public must also become aware of both the power and limitations of computing, particularly with respect to their health and personal data.
技术的进步往往推动着科学发现。因此,研究需要持续投资于最新的设备,并为将要使用这些设备的研究人员提供培训。由于难以预测未来的需求,优先考虑和管理基础设施投资具有挑战性。过去,高计算需求的研究主要与粒子物理和天文实验有关。然而,随着生物学变得更加定量,生物学家生成的数据越来越多,他们的计算需求最终可能超过物理科学家。计算一直是生物信息学的核心,但现在成像实验对数据处理和存储的需求也在迅速增长。还迫切需要新的建模和模拟工具,以提供对这些生物物理实验的深入理解。生物科学界必须共同努力,提供其领域所需的软件和技能培训。有研究活动的机构需要认识到计算现在在许多更广泛的发现领域至关重要,并创造一个可以接受计算的环境。公众也必须意识到计算的强大功能和局限性,特别是在涉及他们的健康和个人数据方面。