Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona.
J Infect Dis. 2019 Aug 30;220(7):1147-1151. doi: 10.1093/infdis/jiz260.
Pneumonic plague, caused by Yersinia pestis, is a rapidly progressing contagious disease. In the plague mouse model, a single immunization with the EV76 live attenuated Y. pestis strain rapidly induced the expression of hemopexin and haptoglobin in the lung and serum, both of which are important in iron sequestration. Immunization against a concomitant lethal Y. pestis respiratory challenge was correlated with temporary inhibition of disease progression. Combining EV76-immunization and second-line antibiotic treatment, which are individually insufficient, led to a synergistic protective effect that represents a proof of concept for efficient combinational therapy in cases of infection with antibiotic-resistant strains.
肺鼠疫由鼠疫耶尔森菌引起，是一种迅速发展的传染病。在鼠疫鼠模型中，单次免疫 EV76 活减毒鼠疫耶尔森菌株可迅速诱导肺和血清中血红素结合蛋白和触珠蛋白的表达，两者在铁螯合中均很重要。针对同时发生的致死性鼠疫耶尔森菌呼吸道感染的免疫接种与疾病进展的暂时抑制相关。EV76 免疫接种和二线抗生素治疗的联合应用（单独应用两者均不足）产生了协同保护作用，为针对耐药菌株感染的有效联合治疗提供了概念验证。
