Zauberman Ayelet, Vagima Yaron, Tidhar Avital, Aftalion Moshe, Gur David, Rotem Shahar, Chitlaru Theodor, Levy Yinon, Mamroud Emanuelle
Department of Biochemistry and Molecular Genetics, Israel Institute for Biological ResearchNess-Ziona, Israel.
Front Cell Infect Microbiol. 2017 Jun 21;7:277. doi: 10.3389/fcimb.2017.00277. eCollection 2017.
Prompt and effective elicitation of protective immunity is highly relevant for cases of rapidly deteriorating fatal diseases, such as plague, which is caused by . Here, we assessed the potential of a live vaccine to induce rapid protection against this infection. We demonstrated that the EV76 live vaccine protected mice against an immediate lethal challenge, limiting the multiplication of the virulent pathogen and its dissemination into circulation. analysis of growth in serum derived from EV76-immunized mice revealed that an antibacterial activity was produced rapidly. This activity was mediated by the host heme- and iron-binding proteins hemopexin and transferrin, and it occurred in strong correlation with the kinetics of hemopexin induction . We suggest a new concept in which a live vaccine is capable of rapidly inducing iron nutritional immunity, thus limiting the propagation of pathogens. This concept could be exploited to design novel therapeutic interventions.
对于由……引起的鼠疫等迅速恶化的致命疾病病例，迅速有效地引发保护性免疫至关重要。在此，我们评估了一种活疫苗诱导针对这种感染的快速保护的潜力。我们证明，EV76活疫苗保护小鼠免受即刻致死性攻击，限制了有毒病原体的增殖及其向循环系统的扩散。对来自EV76免疫小鼠血清中……生长的分析表明，抗菌活性迅速产生。这种活性由宿主血红素和铁结合蛋白血红蛋白和转铁蛋白介导，并且它与血红蛋白诱导的动力学密切相关。我们提出了一个新概念，即活疫苗能够迅速诱导铁营养免疫，从而限制病原体的传播。这一概念可用于设计新的治疗干预措施。
需注意，原文中部分内容表述不完整，如“which is caused by.”后面缺少具体病因信息，翻译时只能尽量根据已有内容准确翻译。
