组织工程学：新进展有哪些？

Tissue Engineering: What is New?

作者信息

Dawson Dolphus R, El-Ghannam Ahmed, Van Sickels Joseph E, Naung Noel Ye

机构信息

Division of Periodontology, Department of Oral Health Practice, College of Dentistry, University of Kentucky, 800 Rose Street, D-444 Dental Sciences Building, Lexington, KY 40536-0297, USA.

Department of Mechanical Engineering and Engineering Science, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 28223-0001, USA.

出版信息

Dent Clin North Am. 2019 Jul;63(3):433-445. doi: 10.1016/j.cden.2019.02.009. Epub 2019 Apr 12.

DOI:10.1016/j.cden.2019.02.009

PMID:31097136

Abstract

Soft and hard tissue engineering has expanded the frontiers of oral/maxillofacial augmentation. Soft tissue grafting enhancements include improving flap prevascularization and using stem cells and other cells to create not only the graft, but also the vascularization and soft tissue scaffolding for the graft. Hard tissue grafts have been enhanced by osteoinductive factors, such as bone morphogenic proteins, that have allowed the elimination of harvesting autogenous bone and thus decrease the need for other surgical sites. Advancements in bone graft scaffolds have developed via seeding with stem cells and improvement of the silica/calcium/phosphate composite to improve graft characteristics and healing.

摘要

软硬组织工程拓展了口腔/颌面修复的前沿领域。软组织移植的改进包括改善皮瓣预血管化，以及使用干细胞和其他细胞不仅创建移植组织，还为移植组织构建血管化和软组织支架。硬组织移植通过骨诱导因子得到了改进，比如骨形态发生蛋白，这使得无需采集自体骨，从而减少了对其他手术部位的需求。骨移植支架的进展是通过接种干细胞以及改进二氧化硅/钙/磷酸盐复合材料来改善移植特性和愈合情况而实现的。