伊维菌素预防致死性寨卡病毒感染的疗效在鼠系统中缺失。
Lack of efficacy of ivermectin for prevention of a lethal Zika virus infection in a murine system.
机构信息
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595.
Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595.
出版信息
Diagn Microbiol Infect Dis. 2019 Sep;95(1):38-40. doi: 10.1016/j.diagmicrobio.2019.03.012. Epub 2019 Mar 29.
Abstract
The antihelminthic drug ivermectin has been demonstrated to have antiviral activity against the Zika virus and other arboviruses in in vitro studies. The effectiveness of ivermectin for Zika virus infection, however, has never been studied in an animal model. In this study, ivermectin was found to be ineffective for prevention of a lethal infection with the Senegal strain of Zika virus in Ifnar1 knockout mice. In view of several study limitations, evaluation of ivermectin's anti-Zika virus activity in other animal models and against other Zika virus strains would be desirable.
摘要
抗蠕虫药物伊维菌素已在体外研究中证明具有抗寨卡病毒和其他虫媒病毒的活性。然而，伊维菌素治疗寨卡病毒感染的效果从未在动物模型中进行过研究。在这项研究中，伊维菌素在 Ifnar1 基因敲除小鼠中对塞内加尔株寨卡病毒的致死性感染无效。鉴于几项研究的局限性，在其他动物模型中和针对其他寨卡病毒株评估伊维菌素的抗寨卡病毒活性是可取的。
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