Restoring tumor suppression.
作者信息
Parsons Ramon
机构信息
The Tisch Cancer Institute at Mount Sinai, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
出版信息
Science. 2019 May 17;364(6441):633-634. doi: 10.1126/science.aax5526.
Abstract
摘要
相似文献
1
Restoring tumor suppression.恢复肿瘤抑制作用。
Science. 2019 May 17;364(6441):633-634. doi: 10.1126/science.aax5526.
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Targeting tumor suppressor networks for cancer therapeutics.针对肿瘤抑制网络的癌症治疗策略。
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[Strategies for the detection and the identification of tumor suppressor genes].[肿瘤抑制基因的检测与鉴定策略]
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Detection of multiple tumor suppressor genes for Syrian hamster fibrosarcomas by somatic cell hybridization.通过体细胞杂交检测叙利亚仓鼠纤维肉瘤的多个肿瘤抑制基因
Somat Cell Mol Genet. 1992 Mar;18(2):131-42. doi: 10.1007/BF01233160.
5
Colony growth suppression by tumor suppressor genes.肿瘤抑制基因对集落生长的抑制作用。
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6
[Tumor-suppressor genes].[肿瘤抑制基因]
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Genetic suppressor elements in the characterization and identification of tumor suppressor genes.
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8
Suppression subtractive hybridization for identification and functional analysis of tumor suppressor genes.用于肿瘤抑制基因鉴定和功能分析的抑制性消减杂交技术
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9
[Tumor suppressor genes. New perspectives for clinical investigations in cancer].[肿瘤抑制基因。癌症临床研究的新视角]
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本文引用的文献
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PTEN function: the long and the short of it.PTEN的功能：其详略情况
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Discovery and saturation analysis of cancer genes across 21 tumour types.在 21 种肿瘤类型中发现和饱和分析癌症基因。
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WWP2 is an E3 ubiquitin ligase for PTEN.WWP2 是 PTEN 的 E3 泛素连接酶。
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Ubiquitination regulates PTEN nuclear import and tumor suppression.泛素化调节PTEN的核输入及肿瘤抑制作用。
Cell. 2007 Jan 12;128(1):141-56. doi: 10.1016/j.cell.2006.11.040.
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Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer.泛素E3连接酶WWP1作为人类前列腺癌中的致癌因子。
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Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression.抑癌基因Pten的单倍剂量不足促进前列腺癌进展。
Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11563-8. doi: 10.1073/pnas.201167798. Epub 2001 Sep 11.
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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice.mTOR抑制剂可降低Pten+/-小鼠的肿瘤形成并使p70/S6激酶活性恢复正常。
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The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene.PTEN/MMAC1肿瘤抑制因子诱导的细胞死亡可被AKT/蛋白激酶B致癌基因挽救。
Cancer Res. 1998 Dec 15;58(24):5667-72.
9
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.肿瘤抑制因子PTEN对依赖蛋白激酶B/蛋白激酶B（PKB/Akt）的细胞存活的负调控。
Cell. 1998 Oct 2;95(1):29-39. doi: 10.1016/s0092-8674(00)81780-8.
10
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.PTEN是一种假定的蛋白酪氨酸磷酸酶基因，在人类脑癌、乳腺癌和前列腺癌中发生突变。
Science. 1997 Mar 28;275(5308):1943-7. doi: 10.1126/science.275.5308.1943.
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