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Senolytic therapies for healthy longevity.

作者信息

van Deursen Jan M

机构信息

Departments of Biochemistry and Molecular Biology, and Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.

出版信息

Science. 2019 May 17;364(6441):636-637. doi: 10.1126/science.aaw1299.

Abstract
摘要

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本文引用的文献

1
Fisetin is a senotherapeutic that extends health and lifespan.
EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29.
2
A versatile drug delivery system targeting senescent cells.
EMBO Mol Med. 2018 Sep;10(9). doi: 10.15252/emmm.201809355.
3
Senolytics improve physical function and increase lifespan in old age.
Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9.
4
Cytoplasmic chromatin triggers inflammation in senescence and cancer.
Nature. 2017 Oct 19;550(7676):402-406. doi: 10.1038/nature24050. Epub 2017 Oct 4.
6
Senescent intimal foam cells are deleterious at all stages of atherosclerosis.
Science. 2016 Oct 28;354(6311):472-477. doi: 10.1126/science.aaf6659. Epub 2016 Oct 27.
7
Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL.
Nat Commun. 2016 Apr 6;7:11190. doi: 10.1038/ncomms11190.
8
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3.
9
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.
Nat Med. 2016 Jan;22(1):78-83. doi: 10.1038/nm.4010. Epub 2015 Dec 14.
10
The role of senescent cells in ageing.
Nature. 2014 May 22;509(7501):439-46. doi: 10.1038/nature13193.

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