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酷似不愈合动脉溃疡的肢端无色素性黑色素瘤

Acral Amelanotic Melanoma Mimicking a Non-Healing Arterial Ulcer.

作者信息

Cantwell Phillip, Van Dam Helena

机构信息

Royal Perth Hospital, Department of Plastic and Reconstructive Surgery, Perth, Washington, Australia.

出版信息

Case Rep Dermatol. 2019 Mar 28;11(1):77-81. doi: 10.1159/000499155. eCollection 2019 Jan-Apr.

DOI:10.1159/000499155
PMID:31097933
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6489097/
Abstract

Acral melanomas contribute to approximately 2-3% of melanomas but are commonly misdiagnosed due to their rarity, subtlety at onset and tendency to display amelanotic features. This case report describes a 70-year-old male with an amelanotic melanoma misdiagnosed as a non-healing arterial ulcer. Histopathology demonstrated a Breslow 2.3 mm, Clark level IV acral lentiginous melanoma, which was definitively managed with surgical intervention. This case report highlights the importance of considering melanoma in the differential diagnosis of non-healing ulcers.

摘要

肢端黑色素瘤约占黑色素瘤的2%-3%,但由于其罕见性、发病初期的隐匿性以及呈现无黑色素特征的倾向,常被误诊。本病例报告描述了一名70岁男性,其无黑色素性黑色素瘤被误诊为不愈合的动脉溃疡。组织病理学显示为Breslow厚度2.3 mm、Clark分级IV级的肢端雀斑样黑色素瘤,通过手术干预得到了明确治疗。本病例报告强调了在不愈合溃疡的鉴别诊断中考虑黑色素瘤的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0013/6489097/3599307343a8/cde-0011-0077-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0013/6489097/53b9a3167fbc/cde-0011-0077-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0013/6489097/03f483636fa3/cde-0011-0077-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0013/6489097/3599307343a8/cde-0011-0077-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0013/6489097/53b9a3167fbc/cde-0011-0077-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0013/6489097/03f483636fa3/cde-0011-0077-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0013/6489097/3599307343a8/cde-0011-0077-g03.jpg

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本文引用的文献

1
Amelanotic melanoma.无色素性黑色素瘤
BMJ. 2018 Mar 15;360:k826. doi: 10.1136/bmj.k826.
2
Acral Melanoma and Mechanical Stress on the Plantar Surface of the Foot.肢端黑色素瘤与足底的机械应力
N Engl J Med. 2017 Jul 27;377(4):395-396. doi: 10.1056/NEJMc1706162.
3
The importance of wound biopsy in the accurate diagnosis of acral malignant melanoma presenting as a foot ulcer.伤口活检在准确诊断表现为足部溃疡的肢端恶性黑色素瘤中的重要性。
Int J Low Extrem Wounds. 2013 Dec;12(4):289-92. doi: 10.1177/1534734613512505. Epub 2013 Dec 9.
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Clinical presentation of acral lentiginous melanoma: a descriptive study.肢端雀斑样痣黑色素瘤的临床表现:一项描述性研究。
Actas Dermosifiliogr. 2013 Apr;104(3):220-6. doi: 10.1016/j.ad.2012.06.006. Epub 2012 Sep 5.