Ishiahara Kentaro, Hashida Noriyasu, Asao Kazunobu, Usui Shinichi, Maruyama Kazuichi, Nishida Kohji
Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
Case Rep Ophthalmol. 2019 Feb 20;10(1):75-80. doi: 10.1159/000497033. eCollection 2019 Jan-Apr.
We report the rare case of an adenoma of the nonpigmented ciliary epithelium (NPCE). A 67-year-old healthy man presented with a regularly shaped and nonpigmented mass at the iris root of his right eye. His best-corrected visual acuity was 1.5 with normal intraocular pressure. During observation, the size of the tumor remained stable for 1.5 years but then rapidly grew, extending through the iris, and gradually enlarged to the point of compressing the iris. Ultimately, an iridocyclectomy with scleral resection under a lamellar scleral flap was performed. The histopathologic features of the resected tissue were consistent with adenoma of the NPCE. Histopathological analysis showed that the tumor consisted of both tubular and solid components. There were solid lesions inside of the ciliary epithelium and tubular lesions outside. We observed positive immunoreactivity to vimentin and cytokeratin CK (AE1/AE3) and negative reactivity to S-100 and CD68, both rarely associated with adenoma of NPCE. During 1 year of follow-up after the iridocyclectomy, no signs of tumor recurrence were observed.
我们报告了一例罕见的非色素睫状上皮（NPCE）腺瘤病例。一名67岁的健康男性右眼虹膜根部出现一个形状规则且无色素的肿块。他的最佳矫正视力为1.5，眼压正常。在观察期间，肿瘤大小在1.5年内保持稳定，但随后迅速生长，穿过虹膜，并逐渐增大至压迫虹膜。最终，在板层巩膜瓣下进行了巩膜切除术联合虹膜睫状体切除术。切除组织的组织病理学特征与NPCE腺瘤一致。组织病理学分析显示，肿瘤由管状和实性成分组成。睫状上皮内部有实性病变，外部有管状病变。我们观察到波形蛋白和细胞角蛋白CK（AE1/AE3）免疫反应呈阳性，而S-100和CD68免疫反应呈阴性，这两种情况在NPCE腺瘤中均很少见。在虹膜睫状体切除术后1年的随访中，未观察到肿瘤复发迹象。
