Cornfield D B, Jencks J, Binder R A, Rath C E
Obstet Gynecol. 1979 Feb;53(2):203-6.
The peripheral blood of 27 women in their third trimester of pregnancy and of 16 control subjects was studied for total WBC counts and total numbers and percentages of T and B lymphocytes, including quantitation of the major immunoglobulin subtypes of the B lymphocytes. Although significant differences were found for percentages of total lymphocytes, T Lymphocytes, and B lymphocytes, the absolute numbers varied only slightly between the 2 study groups. A higher percentage and a higher absolute number of IgG-bearing B lymphocytes were found among pregnant women than among controls. It is concluded that significant quantitative alterations in circulating T and B lymphocytes do not occur in the third trimester of pregnancy; therefore, the concept of impaired cellular immunity, which has often been suggested to occur in this setting, is not supported. A review of the literature on T and B lymphocytes in human pregnancy is presented.
对27名妊娠晚期妇女和16名对照受试者的外周血进行了研究，以检测白细胞总数以及T淋巴细胞和B淋巴细胞的总数及百分比，包括对B淋巴细胞主要免疫球蛋白亚型的定量分析。尽管在总淋巴细胞、T淋巴细胞和B淋巴细胞的百分比方面发现了显著差异，但两个研究组之间的绝对数量仅略有不同。与对照组相比，孕妇中携带IgG的B淋巴细胞百分比更高，绝对数量也更多。结论是，妊娠晚期循环中的T淋巴细胞和B淋巴细胞不会发生显著的定量改变；因此，常被认为在这种情况下会发生的细胞免疫受损的概念并不成立。本文还对人类妊娠中T淋巴细胞和B淋巴细胞的文献进行了综述。
