RO 15 - 8074与RO 19 - 5247的体外活性
In vitro activity of RO 15-8074 and RO 19-5247.
作者信息
Valle T, Jalanko E, Scheinin L, Renkonen O V
出版信息
Eur J Clin Microbiol. 1987 Apr;6(2):167-9. doi: 10.1007/BF02018201.
The in vitro activity of RO 15-8074 (cefetamet) and RO 19-5247, new oral cephalosporins, was compared with that of amoxicillin, cephalexin, cefaclor, cefuroxime and erythromycin against 292 clinical isolates using the agar dilution method. Both RO 15-8074 and RO 19-5247 were very active against Proteus mirabilis, Neisseria gonorrhoeae, Haemophilus influenzae and Streptococcus pyogenes, but less active against Staphylococcus saprophyticus and Enterobacter cloacae. RO 19-5247 was more active than RO 15-8074 against Haemophilus influenzae and Streptococcus viridans.
采用琼脂稀释法，比较了新型口服头孢菌素RO 15 - 8074（头孢他美）和RO 19 - 5247与阿莫西林、头孢氨苄、头孢克洛、头孢呋辛及红霉素对292株临床分离菌的体外活性。RO 15 - 8074和RO 19 - 5247对奇异变形杆菌、淋病奈瑟菌、流感嗜血杆菌及化脓性链球菌均有很强的活性，但对腐生葡萄球菌和阴沟肠杆菌的活性较弱。RO 19 - 5247对流感嗜血杆菌和草绿色链球菌的活性比RO 15 - 8074更强。
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