两种新型口服头孢菌素头孢替姆（Ro 19-5247）和头孢他美酯（Ro 15-8074）的体外抗菌活性比较
Comparative in vitro antibacterial activities of two new oral cephalosporins, ceftetrame (Ro 19-5247) and cefetamet (Ro 15-8074).
作者信息
Chau P Y, Leung Y K, Ng W W, Arnold K
出版信息
Antimicrob Agents Chemother. 1987 Mar;31(3):473-6. doi: 10.1128/AAC.31.3.473.
Abstract
The in vitro activities of two new oral cephalosporins, ceftetrame (Ro 19-5247) and cefetamet (Ro 15-8074), were tested against 990 clinical bacterial isolates in comparison with that of cephalexin. Both compounds were more active than cephalexin against gram-negative bacteria, inhibiting most isolates of the family Enterobacteriaceae at concentrations of less than or equal to 4 micrograms/ml, but were not active against Acinetobacter species, most Pseudomonas species, Campylobacter jejuni, and Flavobacterium meningosepticum. Ceftetrame was also more active than cephalexin against most streptococcal isolates and as active as cephalexin against methicillin-susceptible Staphylococcus aureus; against the latter cefetamet was ineffective.
摘要
对两种新型口服头孢菌素头孢曲嗪（Ro 19-5247）和头孢他美酯（Ro 15-8074）的体外活性进行了测试，以头孢氨苄作为对照，检测对象为990株临床分离菌。这两种化合物对革兰氏阴性菌的活性均强于头孢氨苄，在浓度小于或等于4微克/毫升时能抑制大多数肠杆菌科分离菌，但对不动杆菌属、大多数假单胞菌属、空肠弯曲菌和脑膜败血金黄杆菌无活性。头孢曲嗪对大多数链球菌分离菌的活性也强于头孢氨苄，对甲氧西林敏感金黄色葡萄球菌的活性与头孢氨苄相当；而头孢他美酯对后者无作用。
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