André Carolina Bosso, Chan Daniel Cn, Giannini Marcelo
Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas, São Paulo, Brazil.
Department of Restorative Dentistry, University of Washington School of Dentistry, Seattle, Washington, USA.
Am J Dent. 2018 Nov 15;31(Sp Is B):37B-41B.
To describe the literature findings regarding commercially available antibacterial-containing dental adhesives and the futures perspectives of this field.
High-risk caries patients could yield benefits from restorative materials containing antibacterial properties in order to reduce the recurrent caries formation. Dental adhesives with antibacterial agents may reduce restoration replacement, as recurrent caries is still one of the major reasons for replacing a resin restoration. Literature results of three commercially available adhesives: Gluma 2Bond, Clearfil SE Protect and Peak Universal Bond, containing glutaraldehyde, MDPB and chlorhexidine, respectively indicates that Clearfil SE Protect seems to have better results against oral pathogens and on Streptococcus mutans biofilm. Besides the promising findings, clinical studies are still necessary in order to validate the clinical efficacy when exposed to a more complex environment and the long-term effect of either commercially available materials, experimental antibacterial monomers or antibacterial incorporations. As a suggestion of this article and according to the current scientific trends in this specific field, future directions should focus on restorative materials with therapeutic components targeting the virulence factors of cariogenic biofilm with minimal toxicity and side effects, and long-term action.
Antibacterial-containing dental adhesives may have therapeutic effects, working as an additional source to reduce recurrent caries development in patients with high-risk of caries, and consequently the reduction in restoration replacements.
描述有关市售含抗菌剂牙科粘合剂的文献研究结果以及该领域的未来前景。
高风险龋病患者可从具有抗菌性能的修复材料中获益，以减少继发龋的形成。含抗菌剂的牙科粘合剂可减少修复体的更换，因为继发龋仍是更换树脂修复体的主要原因之一。三种市售粘合剂（分别含有戊二醛、MDPB和洗必泰的Gluma 2Bond、Clearfil SE Protect和Peak Universal Bond）的文献结果表明，Clearfil SE Protect在对抗口腔病原体和变形链球菌生物膜方面似乎有更好的效果。除了这些有前景的发现外，仍需要进行临床研究，以验证在更复杂环境下的临床疗效以及市售材料、实验性抗菌单体或抗菌添加物的长期效果。作为本文的建议，并根据该特定领域的当前科学趋势，未来的方向应集中在具有治疗成分的修复材料上，这些成分靶向致龋生物膜的毒力因子，具有最小的毒性和副作用，并能长期发挥作用。
含抗菌剂的牙科粘合剂可能具有治疗作用，可作为减少高风险龋病患者继发龋发展的额外手段，从而减少修复体的更换。
