Mommsen T P, Andrews P C, Plisetskaya E M
FEBS Lett. 1987 Jul 13;219(1):227-32. doi: 10.1016/0014-5793(87)81222-x.
Piscine (anglerfish, catfish, coho salmon) glucagon-like peptides (GLPs), applied at 3.5 nM, stimulate (1.1-1.9-fold) flux through gluconeogenesis above control levels in isolated trout and salmon hepatocytes. Human GLP-1 and GLP-2 also activate gluconeogenesis, but to a lesser degree than their piscine counterparts. Minor increases of substrate oxidation are noticed at times of peak gluconeogenic activation through GLPs. These hormones, which are derived from the same precursor peptide as glucagon are more potent activators of gluconeogenesis than glucagon when applied at equimolar concentrations, and do not appear to employ cAMP or cGMP as the intracellular messenger in hepatic tissue.
鱼类（安康鱼、鲶鱼、银大麻哈鱼）胰高血糖素样肽（GLPs），以3.5 nM的浓度应用时，可刺激离体鳟鱼和鲑鱼肝细胞的糖异生通量比对照水平增加（1.1 - 1.9倍）。人GLP - 1和GLP - 2也能激活糖异生，但程度低于鱼类的同类物。在通过GLPs激活糖异生达到峰值时，有时会观察到底物氧化略有增加。这些与胰高血糖素来源于同一前体肽的激素，在等摩尔浓度应用时，是比胰高血糖素更强的糖异生激活剂，并且在肝组织中似乎不使用cAMP或cGMP作为细胞内信使。
