Plisetskaya E M, Ottolenghi C, Sheridan M A, Mommsen T P, Gorbman A
Department of Zoology, University of Washington, Seattle 98195.
Gen Comp Endocrinol. 1989 Feb;73(2):205-16. doi: 10.1016/0016-6480(89)90093-2.
Different doses of glucagon and glucagon-like peptide (GLP) isolated from coho salmon, Oncorhynchus kisutch were tested in vivo and in vitro on juvenile coho and chinook (O. tshawytscha) salmon. Results obtained suggest an involvement of these peptides in the regulation of plasma glucose, plasma fatty acids, liver glycogen, and the hepatic enzymes: glycogen phosphorylase, pyruvate kinase, triacylglycerol lipase, and glucose-6-phosphate dehydrogenase. Metabolic effects were more enhanced in summer than either in spring or in autumn. GLP was less effective than glucagon in stimulating glycogenolysis in vivo. Salmon glucagon, especially in low concentrations, was generally more potent metabolically than mammalian (porcine/bovine) glucagon. The interaction between glucagon-family peptides and insulin seems to be different from the one described in mammals: glucagon and GLP either lowered plasma circulating levels of insulin or showed no effect. Only at the time of parr-smolt transformation did GLP slightly elevate plasma insulin levels in coho salmon.
对从银大麻哈鱼（Oncorhynchus kisutch）中分离出的不同剂量的胰高血糖素和胰高血糖素样肽（GLP），在银大麻哈鱼和奇努克鲑（O. tshawytscha）幼鱼上进行了体内和体外试验。所得结果表明，这些肽参与血浆葡萄糖、血浆脂肪酸、肝糖原以及肝酶（糖原磷酸化酶、丙酮酸激酶、三酰甘油脂肪酶和葡萄糖-6-磷酸脱氢酶）的调节。夏季的代谢效应比春季或秋季更为增强。在体内刺激糖原分解方面，GLP的效果不如胰高血糖素。大麻哈鱼胰高血糖素，尤其是低浓度时，在代谢方面通常比哺乳动物（猪/牛）胰高血糖素更有效。胰高血糖素家族肽与胰岛素之间的相互作用似乎与哺乳动物中描述的不同：胰高血糖素和GLP要么降低血浆中胰岛素的循环水平，要么没有影响。仅在幼鱼向稚鱼转变时，GLP才会使银大麻哈鱼的血浆胰岛素水平略有升高。
