Tao Li-Ming, Li Chuan-Hua, Chen Jun, Liu Hui
Hunan Provincial Key Laboratory of Xiangnan Rare-Precious Metals Compounds Research and Application , Xiangnan University , Chenzhou 423000 , China.
J Org Chem. 2019 Jun 7;84(11):6807-6812. doi: 10.1021/acs.joc.9b00580. Epub 2019 May 17.
A novel Co(III)-catalyzed oxidative annulation of aromatic aldehydes with internal alkynes for accessing isocoumarins is described, which is achieved by oxidation, weak chelation-assisted C-H bond functionalization, and annulation cascades with excellent functional group compatibility, high atom economy, and step efficiency. By using environmentally benign and inexpensive poly(ethylene glycol)-400 (PEG-400), the Co/Cu/PEG-400 system could be recycled and reused.
描述了一种新颖的钴（III）催化的芳香醛与内炔烃的氧化环化反应以合成异香豆素，该反应通过氧化、弱螯合辅助的C-H键官能化以及环化串联反应实现，具有出色的官能团兼容性、高原子经济性和步骤效率。通过使用环境友好且廉价的聚乙二醇-400（PEG-400），钴/铜/PEG-400体系能够被回收和重复使用。
