Fine Chemical Laboratory, Department of Chemistry, Indian Institute of Technology Kanpur 208016, Uttar Pradesh, India.
Org Lett. 2017 May 19;19(10):2544-2547. doi: 10.1021/acs.orglett.7b00801. Epub 2017 Apr 27.
A new procedure for oxidative coupling of aromatic and acrylic acids with alkynes has been developed using abundant, nontoxic, and air stable Cp*Co(III) catalyst. The coupling involves initial cyclometalation via weak chelation-assisted C-H bond activation followed by alkyne coordination, insertion, and reductive elimination leading to diverse isocoumarins (α-pyranones) in good yields under mild conditions.
一种新的方法，用于芳基和丙烯酸与炔烃的氧化偶联，已经使用丰富、无毒和空气稳定的 Cp*Co(III)催化剂开发出来。该偶联涉及初始通过弱螯合辅助的 C-H 键活化的环金属化，然后是炔烃配位、插入和还原消除，在温和条件下以良好的收率得到多种异香豆素（α-吡喃酮）。
