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“呼吸”血凝素揭示了通用流感疫苗设计的隐匿表位。

"Breathing" Hemagglutinin Reveals Cryptic Epitopes for Universal Influenza Vaccine Design.

机构信息

Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences (CAS), 100101 Beijing, China.

Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences (CAS), 100101 Beijing, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 100101 Beijing, China.

出版信息

Cell. 2019 May 16;177(5):1086-1088. doi: 10.1016/j.cell.2019.04.034.

DOI:10.1016/j.cell.2019.04.034
PMID:31100263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7112349/
Abstract

A universal vaccine against influenza remains a critical target, and efforts have recently focused on the stem of the hemagglutinin glycoprotein. In this issue of Cell and a related Cell Host & Microbe article, three studies identify broad protective epitopes in the hemagglutinin head domain that are exposed by trimer "breathing."

摘要

通用流感疫苗仍然是一个关键目标，最近的研究重点集中在血凝素糖蛋白的茎部。在本期《细胞》杂志和相关的《细胞宿主与微生物》文章中，三项研究确定了血凝素头部结构域中暴露的三聚体“呼吸”时的广谱保护性表位。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4891/7112349/53474076e33f/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4891/7112349/53474076e33f/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4891/7112349/53474076e33f/gr1_lrg.jpg

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