McCarthy Cormac, Jayawardena Nadishka, Burga Laura N, Bostina Mihnea
Department of Microbiology and Immunology, University of Otago, Dunedin 9016, New Zealand.
Otago Micro and Nano Imaging, University of Otago, Dunedin 9016, New Zealand.
Cancers (Basel). 2019 May 16;11(5):685. doi: 10.3390/cancers11050685.
Oncolytic viruses (OVs) form a group of novel anticancer therapeutic agents which selectively infect and lyse cancer cells. Members of several viral families, including , have been shown to have anticancer activity. Picornaviruses are small icosahedral non-enveloped, positive-sense, single-stranded RNA viruses infecting a wide range of hosts. They possess several advantages for development for cancer therapy: Their genomes do not integrate into host chromosomes, do not encode oncogenes, and are easily manipulated as cDNA. This review focuses on the picornaviruses investigated for anticancer potential and the mechanisms that underpin this specificity.
溶瘤病毒（OVs）是一类新型抗癌治疗药物，可选择性感染并裂解癌细胞。包括……在内的几个病毒家族的成员已被证明具有抗癌活性。小核糖核酸病毒是小型二十面体无包膜的正链单链RNA病毒，可感染多种宿主。它们在癌症治疗开发方面具有几个优势：其基因组不会整合到宿主染色体中，不编码致癌基因，并且易于作为cDNA进行操作。本综述重点关注已研究其抗癌潜力的小核糖核酸病毒以及支撑这种特异性的机制。
