Folkhälsan Research Center, Helsinki, Finland.
Gerontology Research Centre, Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland.
BMJ Open. 2019 May 16;9(5):e026280. doi: 10.1136/bmjopen-2018-026280.
To examine the relationships of late-career physical heaviness of work and sitting at work with mortality. A national-level job exposure matrix was used to determine the occupation-specific level of physical heaviness and sitting.
Prospective cohort study between years 1990 and 2015.
Community.
5210 men and 4725 women from the Helsinki Birth Cohort Study with an occupational code at baseline (ages 45-57 years).
Total, cardiovascular (International Classification of Diseases 10th Revision I00-I99), cancer (C00-C97) and external (S00-Y84) mortality.
The exposures, physical heaviness and sitting had a non-linear, inverse relationship. During the 26-year follow-up, 1536 men and 759 women died. Among men, physical heaviness of work was positively associated and sitting at work was negatively associated with all-cause, cardiovascular and external cause mortality but they were not associated with cancer mortality. The HRs for men in the highest quartile of physical heaviness of work compared with men in the lowest quartile were 1.54 (1.31-1.80) for all-cause mortality, 1.70 (1.30-2.23) for cardiovascular mortality and 3.18 (1.75-5.78) for external cause mortality (adjusted for age and years of education). Compared with the lowest quartile, the HRs for the highest quartile of sitting at work among men were 0.71 (0.61-0.82) for all-cause mortality, 0.59 (0.45-0.77) for cardiovascular mortality and 0.38 (0.22-0.66) for external cause mortality. In women, neither physical heaviness of work nor sitting at work was associated with mortality.
Men in physically heavy work at their late-work career are at higher risk of death than men in physically light work.
探讨职业生涯后期工作时身体负荷和久坐与死亡率的关系。使用国家级工作暴露矩阵来确定特定职业的身体负荷和久坐程度。
1990 年至 2015 年期间的前瞻性队列研究。
社区。
来自赫尔辛基出生队列研究的 5210 名男性和 4725 名女性，在基线时（45-57 岁）有职业代码。
总死亡率、心血管疾病（国际疾病分类第 10 版 I00-I99）、癌症（C00-C97）和外部（S00-Y84）死亡率。
暴露因素，即身体负荷和久坐，呈非线性反比关系。在 26 年的随访期间，有 1536 名男性和 759 名女性死亡。在男性中，工作时的身体负荷与全因、心血管和外部原因死亡率呈正相关，而工作时的久坐与全因、心血管和外部原因死亡率呈负相关，但与癌症死亡率无关。与身体负荷最低四分位的男性相比，身体负荷最高四分位的男性全因死亡率的 HR 为 1.54（1.31-1.80），心血管死亡率为 1.70（1.30-2.23），外部原因死亡率为 3.18（1.75-5.78）（调整年龄和受教育年限）。与最低四分位相比，工作时久坐最高四分位的男性全因死亡率的 HR 为 0.71（0.61-0.82），心血管死亡率的 HR 为 0.59（0.45-0.77），外部原因死亡率的 HR 为 0.38（0.22-0.66）。在女性中，工作时的身体负荷和久坐都与死亡率无关。
在职业生涯后期从事体力劳动的男性比从事体力劳动较轻的男性死亡风险更高。
