Olga Tennison Autism Research Centre, School of Psychology and Public Health, College of Science, Health and Engineering, La Trobe University, Plenty Road & Kingsbury Drive, Melbourne, VIC, 3086, Australia.
Cooperative Research Centre for Living with Autism (Autism CRC), Brisbane, Australia.
J Autism Dev Disord. 2019 Aug;49(8):3401-3411. doi: 10.1007/s10803-019-04052-7.
Previous research has found multiplex (MPX) children have an advantage in cognition compared to simplex (SPX) children. However, MPX parent's previous experience with older diagnosed siblings has not been considered. We used a large database sample to investigate the MPX advantage and contribution of birth order. Children from the Autism Genetic Resource Exchange (AGRE) were stratified into first- (MPX, n = 152) and second-affected MPX (MPX, n = 143), SPX (n = 111), and only-child SPX (SPX, n = 23) groups. Both MPX groups had higher cognitive scores compared to SPX groups, with no differences between MPX and MPX groups. No differences were found for autism symptoms or adaptive behaviour. These results suggest parent experience due to birth order is an unlikely contributor to the MPX cognitive advantage.
先前的研究发现，与单纯型（SPX）患儿相比，多发性（MPX）患儿在认知方面具有优势。然而，MPX 患儿的父母先前有其他已确诊的大龄患儿的经历并未被考虑在内。我们使用一个大型数据库样本来调查 MPX 优势和出生顺序的影响。自闭症基因资源交换（AGRE）的儿童分为第一（MPX，n = 152）和第二受影响的 MPX（MPX，n = 143）、SPX（n = 111）和仅为儿童的 SPX（SPX，n = 23）组。与 SPX 组相比，两组 MPX 患儿的认知评分均较高，而 MPX 组与 MPX 组之间无差异。自闭症症状或适应行为无差异。这些结果表明，由于出生顺序导致的父母经验不太可能是 MPX 认知优势的原因。
