纳米医学对眼部药物输送的治疗意义。
Therapeutic implications of nanomedicine for ocular drug delivery.
机构信息
Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA; Center for Pharmaceutical Engineering and Sciences, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA.
Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA; Center for Pharmaceutical Engineering and Sciences, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA; Department of Physics, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, VA 23284, USA.
出版信息
Drug Discov Today. 2019 Aug;24(8):1524-1538. doi: 10.1016/j.drudis.2019.05.006. Epub 2019 May 15.
Delivering therapeutics to the eye is challenging on multiple levels: rapid clearance of eyedrops from the ocular surface requires frequent instillation, which is difficult for patients; transport of drugs across the blood-retinal barrier when drugs are administered systemically, and the cornea when drugs are administered topically, is difficult to achieve; limited drug penetration to the back of the eye owing to the cornea, conjunctiva, sclera and vitreous barriers. Nanomedicine offers many advantages over conventional ophthalmic medications for effective ocular drug delivery because nanomedicine can increase the therapeutic index by overcoming ocular barriers, improving drug-release profiles and reducing potential drug toxicity. In this review, we highlight the therapeutic implications of nanomedicine for ocular drug delivery.
将治疗药物递送到眼部在多个层面上具有挑战性
眼药水从眼部表面迅速清除需要频繁滴注，这对患者来说很困难；当药物全身给药时，药物穿过血视网膜屏障，以及当药物局部给药时，药物穿过角膜，这很难实现；由于角膜、结膜、巩膜和玻璃体的屏障作用，药物有限地渗透到眼睛后部。与传统的眼科药物相比，纳米医学在有效的眼部药物递送方面具有许多优势，因为纳米医学可以通过克服眼部屏障、改善药物释放特性和降低潜在药物毒性来提高治疗指数。在这篇综述中，我们强调了纳米医学在眼部药物递送中的治疗意义。
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