Biomaterials and Regenerative Medicine Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, United States.
Biomaterials and Regenerative Medicine Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, United States.
Adv Drug Deliv Rev. 2019 Sep-Oct;149-150:85-94. doi: 10.1016/j.addr.2019.05.005. Epub 2019 May 16.
Macrophages are major upstream regulators of the inflammatory response to implanted biomaterials. Sequential functions of distinct macrophage phenotypes are essential to the normal tissue repair process, which ideally results in vascularization and integration of implants. Improper timing of M1 or M2 macrophage activation results in dysfunctional healing in the form of chronic inflammation or fibrous encapsulation of the implant. Thus, biphasic drug delivery systems that modulate macrophage behavior are an appealing approach to promoting implant integration. In this review, we describe the timing and roles of macrophage phenotypes in healing, then highlight current drug delivery systems designed to sequentially modulate macrophage behavior.
巨噬细胞是植入生物材料引发炎症反应的主要上游调控者。不同表型的巨噬细胞的连续功能对于正常的组织修复过程至关重要，理想情况下会导致血管生成和植入物的整合。M1 或 M2 巨噬细胞激活时机不当会导致慢性炎症或植入物纤维包裹等功能失调的愈合。因此，调节巨噬细胞行为的两相药物传递系统是促进植入物整合的一种有吸引力的方法。在这篇综述中，我们描述了巨噬细胞表型在愈合过程中的时间和作用，然后重点介绍了目前设计用于连续调节巨噬细胞行为的药物传递系统。
