Kallikrein-related peptidase 8 基因敲除小鼠尽管具有正常的社交趋近行为，但仍存在社交辨别能力受损的现象。
Impaired social discrimination behavior despite normal social approach by kallikrein-related peptidase 8 knockout mouse.
机构信息
Department of Functional Anatomy and Neuroscience, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.
Department of Systems Life Engineering, Maebashi Institute of Technology, Maebashi, Gunma 371-0816, Japan.
出版信息
Neurobiol Learn Mem. 2019 Jul;162:47-58. doi: 10.1016/j.nlm.2019.04.014. Epub 2019 May 16.
For social mammals, recognition of conspecifics and discrimination of each other (social memory) is crucial to living in a stable colony. Here, we investigated whether kallikrein-related peptidase 8 (KLK8)-neuregulin 1 (NRG1)-ErbB signaling is crucial for social discrimination behavior using the social discrimination three chamber behavioral test. Klk8 knockout mice (NRG1-deactivated mice) exhibited normal social approach but impaired social discrimination. Intraventricular injection of recombinant NRG1 into Klk8 knockout mice reversed this impaired social discrimination. This study reveals that KLK8 is a key regulator of NRG1-ErbB signaling, which contributes to social discrimination behavior.
对于社会性哺乳动物而言，识别同种动物和区分彼此（社会记忆）对于生活在稳定的群体中至关重要。在这里，我们使用社会辨别三箱行为测试来研究激肽释放酶相关肽酶 8 (KLK8)-神经调节蛋白 1 (NRG1)-表皮生长因子受体 (ErbB) 信号是否对社会辨别行为至关重要。Klk8 敲除小鼠（NRG1 失活小鼠）表现出正常的社交接近，但社交辨别受损。向 Klk8 敲除小鼠脑室内注射重组 NRG1 可逆转这种受损的社交辨别。本研究揭示 KLK8 是 NRG1-ErbB 信号的关键调节剂，有助于社会辨别行为。
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